Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics

Anders G Holst; Siamak Saber; Massoud Houshmand; Elena V Zaklyazminskaya; Yinman Wang; Henrik Kjærulf Jensen; Lena Refsgaard; Stig Haunsø; Jesper Hastrup Svendsen; Morten S Olesen; Jacob Tfelt-Hansen

doi:10.1016/j.cjca.2011.11.011

Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics

Anders G Holst, Siamak Saber, Massoud Houshmand, Elena V Zaklyazminskaya, Yinman Wang, Henrik Kjærulf Jensen, Lena Refsgaard, Stig Haunsø, Jesper Hastrup Svendsen, Morten S Olesen, Jacob Tfelt-Hansen

20 Citations (Scopus)

Abstract

Brugada syndrome (BrS) is a primary arrhythmia syndrome characterized by the occurrence of malignant ventricular arrhythmias. Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS. Recent data from exome screening efforts permit better discrimination between low-frequency genetic variants and true monogenetic disease-causing variants. We aimed to screen the genes SCN1B through SCN4B, MOG1, CAV3, and KCND3 for variations in a population of SCN5A negative Danish and Iranian BrS patients, as well as research prior associations using newly released exome data.

Original language	English
Journal	The Canadian journal of cardiology
Volume	28
Issue number	2
Pages (from-to)	196-200
Number of pages	5
DOIs	https://doi.org/10.1016/j.cjca.2011.11.011
Publication status	Published - 2012

Keywords

Adult
Brugada Syndrome
Computational Biology
Female
Genetic Testing
Humans
Male
Middle Aged
Potassium
Sodium
Sodium Channels
Voltage-Gated Sodium Channel beta-1 Subunit

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Holst, A. G., Saber, S., Houshmand, M., Zaklyazminskaya, E. V., Wang, Y., Jensen, H. K., Refsgaard, L., Haunsø, S., Svendsen, J. H., Olesen, M. S., & Tfelt-Hansen, J. (2012). Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics. The Canadian journal of cardiology, 28(2), 196-200. https://doi.org/10.1016/j.cjca.2011.11.011

Holst, AG, Saber, S, Houshmand, M, Zaklyazminskaya, EV, Wang, Y, Jensen, HK, Refsgaard, L, Haunsø, S , Svendsen, JH, Olesen, MS & Tfelt-Hansen, J 2012, 'Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics', The Canadian journal of cardiology, vol. 28, no. 2, pp. 196-200. https://doi.org/10.1016/j.cjca.2011.11.011

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title = "Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics",

abstract = "Brugada syndrome (BrS) is a primary arrhythmia syndrome characterized by the occurrence of malignant ventricular arrhythmias. Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS. Recent data from exome screening efforts permit better discrimination between low-frequency genetic variants and true monogenetic disease-causing variants. We aimed to screen the genes SCN1B through SCN4B, MOG1, CAV3, and KCND3 for variations in a population of SCN5A negative Danish and Iranian BrS patients, as well as research prior associations using newly released exome data.",

keywords = "Adult, Brugada Syndrome, Computational Biology, Female, Genetic Testing, Humans, Male, Middle Aged, Potassium, Sodium, Sodium Channels, Voltage-Gated Sodium Channel beta-1 Subunit",

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doi = "10.1016/j.cjca.2011.11.011",

language = "English",

volume = "28",

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T2 - screening and bioinformatics

AU - Holst, Anders G

AU - Saber, Siamak

AU - Houshmand, Massoud

AU - Zaklyazminskaya, Elena V

AU - Wang, Yinman

AU - Jensen, Henrik Kjærulf

AU - Refsgaard, Lena

AU - Haunsø, Stig

AU - Svendsen, Jesper Hastrup

AU - Olesen, Morten S

AU - Tfelt-Hansen, Jacob

PY - 2012

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AB - Brugada syndrome (BrS) is a primary arrhythmia syndrome characterized by the occurrence of malignant ventricular arrhythmias. Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS. Recent data from exome screening efforts permit better discrimination between low-frequency genetic variants and true monogenetic disease-causing variants. We aimed to screen the genes SCN1B through SCN4B, MOG1, CAV3, and KCND3 for variations in a population of SCN5A negative Danish and Iranian BrS patients, as well as research prior associations using newly released exome data.

KW - Adult

KW - Brugada Syndrome

KW - Computational Biology

KW - Female

KW - Genetic Testing

KW - Humans

KW - Male

KW - Middle Aged

KW - Potassium

KW - Sodium

KW - Sodium Channels

KW - Voltage-Gated Sodium Channel beta-1 Subunit

UR - https://www.scopus.com/pages/publications/84862776540

U2 - 10.1016/j.cjca.2011.11.011

DO - 10.1016/j.cjca.2011.11.011

M3 - Journal article

C2 - 22284586

SN - 1916-7075

VL - 28

SP - 196

EP - 200

JO - The Canadian journal of cardiology

JF - The Canadian journal of cardiology

IS - 2

ER -

Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics

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