Sodium current and potassium transient outward current genes in Brugada syndrome: screening and bioinformatics

Anders G Holst, Siamak Saber, Massoud Houshmand, Elena V Zaklyazminskaya, Yinman Wang, Henrik Kjærulf Jensen, Lena Refsgaard, Stig Haunsø, Jesper Hastrup Svendsen, Morten S Olesen, Jacob Tfelt-Hansen

    20 Citations (Scopus)

    Abstract

    Brugada syndrome (BrS) is a primary arrhythmia syndrome characterized by the occurrence of malignant ventricular arrhythmias. Previously, the genes SCN1B, SCN3B, MOG1, and KCND3 have been associated with BrS. Recent data from exome screening efforts permit better discrimination between low-frequency genetic variants and true monogenetic disease-causing variants. We aimed to screen the genes SCN1B through SCN4B, MOG1, CAV3, and KCND3 for variations in a population of SCN5A negative Danish and Iranian BrS patients, as well as research prior associations using newly released exome data.
    Original languageEnglish
    JournalThe Canadian journal of cardiology
    Volume28
    Issue number2
    Pages (from-to)196-200
    Number of pages5
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Adult
    • Brugada Syndrome
    • Computational Biology
    • Female
    • Genetic Testing
    • Humans
    • Male
    • Middle Aged
    • Potassium
    • Sodium
    • Sodium Channels
    • Voltage-Gated Sodium Channel beta-1 Subunit

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