Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study

Camilla Jerlang Christiani; Jens R M Jepsen; Anne Thorup; Nicoline Hemager; Ditte Ellersgaard; Katrine S Spang; Birgitte K Burton; Maja Gregersen; Anne Søndergaard; Aja N Greve; Ditte L Gantriis; Gry Poulsen; Md Jamal Uddin; Larry J Seidman; Ole Mors; Kerstin J Plessen; Merete Nordentoft

doi:10.1093/schbul/sbz001

Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study

Camilla Jerlang Christiani, Jens R M Jepsen, Anne Thorup, Nicoline Hemager, Ditte Ellersgaard, Katrine S Spang, Birgitte K Burton, Maja Gregersen, Anne Søndergaard, Aja N Greve, Ditte L Gantriis, Gry Poulsen, Md Jamal Uddin, Larry J Seidman, Ole Mors, Kerstin J Plessen, Merete Nordentoft

38 Citations (Scopus)

Abstract

OBJECTIVE: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP).

METHODS: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior.

RESULTS: The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P = .006; pragmatic: d = -0.51, P < .001), social responsiveness (d = -0.54, P < .001), and adaptive social functioning (d = -0.47, P < .001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P = .007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction.

CONCLUSION: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.

Original language	English
Journal	Schizophrenia Bulletin
Volume	45
Issue number	6
Pages (from-to)	1218-1230
Number of pages	13
ISSN	0586-7614
DOIs	https://doi.org/10.1093/schbul/sbz001
Publication status	Published - 24 Oct 2019

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Christiani, C. J., Jepsen, J. R. M., Thorup, A., Hemager, N., Ellersgaard, D., Spang, K. S., Burton, B. K., Gregersen, M., Søndergaard, A., Greve, A. N., Gantriis, D. L., Poulsen, G., Uddin, M. J., Seidman, L. J., Mors, O., Plessen, K. J., & Nordentoft, M. (2019). Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study. Schizophrenia Bulletin, 45(6), 1218-1230. https://doi.org/10.1093/schbul/sbz001

Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study. / Christiani, Camilla Jerlang; Jepsen, Jens R M ; Thorup, Anne et al.
In: Schizophrenia Bulletin, Vol. 45, No. 6, 24.10.2019, p. 1218-1230.

Research output: Contribution to journal › Journal article › Research › peer-review

Christiani, CJ, Jepsen, JRM , Thorup, A , Hemager, N, Ellersgaard, D, Spang, KS , Burton, BK , Gregersen, M , Søndergaard, A, Greve, AN, Gantriis, DL, Poulsen, G, Uddin, MJ, Seidman, LJ, Mors, O, Plessen, KJ & Nordentoft, M 2019, 'Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study', Schizophrenia Bulletin, vol. 45, no. 6, pp. 1218-1230. https://doi.org/10.1093/schbul/sbz001

Christiani CJ, Jepsen JRM , Thorup A , Hemager N, Ellersgaard D, Spang KS et al. Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study. Schizophrenia Bulletin. 2019 Oct 24;45(6):1218-1230. doi: 10.1093/schbul/sbz001

@article{c3217fb2fc4a4ccebd2e9e04cb53d286,

title = "Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study",

abstract = "OBJECTIVE: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP).METHODS: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior.RESULTS: The analysis included 202 FHR-SZ children (girls: 46\%), 120 FHR-BP children (girls: 46.7\%), and 200 controls (girls: 46.5\%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P = .006; pragmatic: d = -0.51, P < .001), social responsiveness (d = -0.54, P < .001), and adaptive social functioning (d = -0.47, P < .001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P = .007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction.CONCLUSION: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.",

author = "Christiani, \{Camilla Jerlang\} and Jepsen, \{Jens R M\} and Anne Thorup and Nicoline Hemager and Ditte Ellersgaard and Spang, \{Katrine S\} and Burton, \{Birgitte K\} and Maja Gregersen and Anne S{\o}ndergaard and Greve, \{Aja N\} and Gantriis, \{Ditte L\} and Gry Poulsen and Uddin, \{Md Jamal\} and Seidman, \{Larry J\} and Ole Mors and Plessen, \{Kerstin J\} and Merete Nordentoft",

note = "{\textcopyright} The Author(s) 2019. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.All rights reserved. For permissions, please email: [email protected].",

year = "2019",

month = oct,

day = "24",

doi = "10.1093/schbul/sbz001",

language = "English",

volume = "45",

pages = "1218--1230",

journal = "Schizophrenia Bulletin",

issn = "0586-7614",

publisher = "Oxford University Press",

number = "6",

}

TY - JOUR

T1 - Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder

T2 - The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study

AU - Christiani, Camilla Jerlang

AU - Jepsen, Jens R M

AU - Thorup, Anne

AU - Hemager, Nicoline

AU - Ellersgaard, Ditte

AU - Spang, Katrine S

AU - Burton, Birgitte K

AU - Gregersen, Maja

AU - Søndergaard, Anne

AU - Greve, Aja N

AU - Gantriis, Ditte L

AU - Poulsen, Gry

AU - Uddin, Md Jamal

AU - Seidman, Larry J

AU - Mors, Ole

AU - Plessen, Kerstin J

AU - Nordentoft, Merete

PY - 2019/10/24

Y1 - 2019/10/24

N2 - OBJECTIVE: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP).METHODS: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior.RESULTS: The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P = .006; pragmatic: d = -0.51, P < .001), social responsiveness (d = -0.54, P < .001), and adaptive social functioning (d = -0.47, P < .001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P = .007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction.CONCLUSION: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.

AB - OBJECTIVE: To characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP).METHODS: The Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior.RESULTS: The analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P = .006; pragmatic: d = -0.51, P < .001), social responsiveness (d = -0.54, P < .001), and adaptive social functioning (d = -0.47, P < .001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P = .007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction.CONCLUSION: Language, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.

UR - https://www.scopus.com/pages/publications/85067109144

U2 - 10.1093/schbul/sbz001

DO - 10.1093/schbul/sbz001

M3 - Journal article

C2 - 30852621

SN - 0586-7614

VL - 45

SP - 1218

EP - 1230

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

IS - 6

ER -

Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study

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