TY - JOUR
T1 - Smoking as a prognostic factor for survival in patients with disseminated germ cell cancer
AU - Bandak, Mikkel
AU - Nielsen, Kristine Skovly
AU - Kreiberg, Michael
AU - Wagner, Thomas
AU - Rosenvilde, Josephine
AU - Pisinger, Charlotta
AU - Johansen, Christoffer
AU - Daugaard, Gedske
AU - Lauritsen, Jakob
N1 - © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected].
PY - 2023/6/8
Y1 - 2023/6/8
N2 - We investigated the impact of smoking on overall survival (OS) in testicular germ cell cancer (TC) patients receiving first-line combination chemotherapy (bleomycin-etoposide-cisplatin [BEP]). Patients who received BEP for metastatic TC were identified in the Danish Testicular Cancer database. Information on smoking status at the time of diagnosis was obtained by medical record review. OS and cause of death were compared between current smokers and never-smokers. Of 1883 eligible patients, information on smoking status was available in 1156 patients, of whom 602 were current smokers. The 10-year OS was 92% in never-smokers compared with 83% in current smokers (P < .001) (hazard ratio for death = 1.85, 95% confidence interval = 1.29 to 2.66, P = .001). A higher proportion of current smokers died of TC compared with nonsmokers (P < .01). Smoking negatively affects survival after BEP in patients with disseminated TC. Vigorous smoking cessation programs are advocated in TC patients.
AB - We investigated the impact of smoking on overall survival (OS) in testicular germ cell cancer (TC) patients receiving first-line combination chemotherapy (bleomycin-etoposide-cisplatin [BEP]). Patients who received BEP for metastatic TC were identified in the Danish Testicular Cancer database. Information on smoking status at the time of diagnosis was obtained by medical record review. OS and cause of death were compared between current smokers and never-smokers. Of 1883 eligible patients, information on smoking status was available in 1156 patients, of whom 602 were current smokers. The 10-year OS was 92% in never-smokers compared with 83% in current smokers (P < .001) (hazard ratio for death = 1.85, 95% confidence interval = 1.29 to 2.66, P = .001). A higher proportion of current smokers died of TC compared with nonsmokers (P < .01). Smoking negatively affects survival after BEP in patients with disseminated TC. Vigorous smoking cessation programs are advocated in TC patients.
KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
KW - Bleomycin/adverse effects
KW - Cisplatin/adverse effects
KW - Etoposide/adverse effects
KW - Humans
KW - Male
KW - Neoplasms, Germ Cell and Embryonal/therapy
KW - Prognosis
KW - Smoking/adverse effects
KW - Testicular Neoplasms/pathology
UR - http://www.scopus.com/inward/record.url?scp=85163237538&partnerID=8YFLogxK
U2 - 10.1093/jnci/djad039
DO - 10.1093/jnci/djad039
M3 - Journal article
C2 - 36806937
SN - 1460-2105
VL - 115
SP - 753
EP - 756
JO - JNCI-Journal of the National Cancer Institute
JF - JNCI-Journal of the National Cancer Institute
IS - 6
ER -