Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Small-scale geographical variation in multiple sclerosis: A case-control study using Danish register data 1971-2013

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Illegal cannabis use is common among Danes with multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Multiple sclerosis and cancer incidence: A Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Multiple sclerosis registries in Europe - An updated mapping survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The role of gluten in multiple sclerosis: A systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  5. Clinical utility of anti-MOG antibody testing in a Danish cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Illegal cannabis use is common among Danes with multiple sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Multiple sclerosis and cancer incidence: A Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Multiple sclerosis registries in Europe - An updated mapping survey

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: The aetiology of multiple sclerosis (MS) is largely unknown, but commonly assumed to be a complex interaction between genes and environmental exposures, presumably during early life. To evaluate the possible importance and timing of environmental exposures we investigated the spatial variation in the risk of MS in Denmark according to residence at birth, age 15, and clinical onset of disease.

METHODS: We carried out a nationwide, register-based case-control study including 12 993 Danish MS cases with onset of disease 1971-2013. Information on exact residential addresses was available for all study subjects in the Danish Civil Registration System. The spatial variation in risk of MS was estimated by kernel regression.

RESULTS: We identified spatial variation in the risk of MS according to residence at birth, age 15, and onset of disease. Several high- and low-risk areas were identified across the country with some variation between birth, age 15, and onset.

CONCLUSIONS: Small-scale geographical variation in the risk of MS suggests that local environmental risk factors could be at play and may be related to life style factors.

Original languageEnglish
JournalMultiple Sclerosis and Related Disorders
Volume23
Pages (from-to)40-45
Number of pages6
ISSN2211-0348
DOIs
Publication statusPublished - Jul 2018

    Research areas

  • Adult, Case-Control Studies, Denmark/epidemiology, Female, Geography, Medical, Humans, Male, Multiple Sclerosis/epidemiology, Registries, Regression Analysis, Risk Factors

ID: 56320345