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Small Hard Macular Drusen and Associations in 11- to 12-Year-Old Children in the Copenhagen Child Cohort 2000 Eye Study

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  3. Cohort Profile: The Copenhagen Child Cohort Study (CCC2000)

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  4. Retinal arteriolar wall-to-lumen ratios at 16-17 years in the Copenhagen Child Cohort 2000 Study

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Purpose: To assess the prevalence and associations of small hard drusen in a child cohort.

Methods: Cross-sectional study of 11- to 12-year-old Danish children from the population-based Copenhagen Child Cohort 2000 Eye Study. Fovea-centered, 45° color images of both eyes were graded for macular drusen (within one optic-disc-rim-to-fovea distance of the foveal center) and for extramacular drusen. Analyses tested for associations between drusen and anthropometric measures including choroidal thickness.

Results: Gradable fundus images from both eyes were available for 1333 children (640 boys, 693 girls) with a mean (SD) age of 11.7 (0.40) years. One or more small hard macular drusen (diameter <63 μm) were present in 82 (6.2%) right eyes and 82 (6.2%) left eyes and in 147 (11.0%) subjects. Four children (0.30%) had 20 or more small hard macular drusen in one or both eyes. Extramacular small hard drusen were present in 10.7% of children, and 19% of children had such drusen anywhere. The odds for having one or more small hard macular drusen increased with subfoveal choroidal thickness with an odds ratio of 1.15 (95% confidence interval, 1.03-1.28; P = 0.013) per 50-μm thicker choroid, adjusted for age and sex. The association with choroidal thickness was also present for extramacular drusen.

Conclusions: Having one or more small hard macular drusen was common in 11- to 12-year old children and it was associated with a thicker subfoveal choroid. Few children had many small hard drusen. There is no apparent clinical impact of small hard drusen in childhood.

Original languageEnglish
JournalInvestigative ophthalmology & visual science
Volume60
Issue number5
Pages (from-to)1454-1460
Number of pages7
ISSN0146-0404
DOIs
Publication statusPublished - 1 Apr 2019

    Research areas

  • Child, Choroid/pathology, Cross-Sectional Studies, Denmark/epidemiology, Female, Humans, Macula Lutea/pathology, Male, Prevalence, Retinal Drusen/epidemiology

ID: 58410013