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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Sleep transitions in hypocretin-deficient narcolepsy

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  1. Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy

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  2. Cerebrospinal fluid biomarkers of neurodegeneration are decreased or normal in narcolepsy

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  3. Breathing Disturbances Without Hypoxia Are Associated With Objective Sleepiness in Sleep Apnea

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  4. Onset of Impaired Sleep and Cardiovascular Disease Risk Factors: A Longitudinal Study

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  5. HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency

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  1. Long-term health and socioeconomic consequences of childhood and adolescent-onset of narcolepsy

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  2. The role of sleep in the pathophysiology of nocturnal enuresis

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  3. CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

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  4. External validation of a data-driven algorithm for muscular activity identification during sleep

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  5. Rapid eye movements are reduced in blind individuals

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Narcolepsy is characterized by instability of sleep-wake, tonus, and rapid eye movement (REM) sleep regulation. It is associated with severe hypothalamic hypocretin deficiency, especially in patients with cataplexy (loss of tonus). As the hypocretin neurons coordinate and stabilize the brain's sleep-wake pattern, tonus, and REM flip-flop neuronal centers in animal models, we set out to determine whether hypocretin deficiency and/or cataplexy predicts the unstable sleep-wake and REM sleep pattern of the human phenotype.
Original languageEnglish
JournalSleep
Volume36
Issue number8
Pages (from-to)1173-7
Number of pages5
ISSN0161-8105
DOIs
Publication statusPublished - Aug 2013

ID: 42956239