Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis

Anne-Sofie Halling; Maria Rasmussen Rinnov; Iben Frier Ruge; Trine Gerner; Nina Haarup Ravn; Mette Hjorslev Knudgaard; Simon Trautner; Nikolai Loft; Lone Skov; Simon F Thomsen; Alexander Egeberg; Emma Guttman-Yassky; Aske L L Rosted; Troels Petersen; Ivone Jakasa; Sanja Kezic; Jacob P Thyssen

doi:10.1016/j.jaci.2022.11.023

Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis

Anne-Sofie Halling, Maria Rasmussen Rinnov, Iben Frier Ruge, Trine Gerner, Nina Haarup Ravn, Mette Hjorslev Knudgaard, Simon Trautner, Nikolai Loft, Lone Skov, Simon F Thomsen, Alexander Egeberg, Emma Guttman-Yassky, Aske L L Rosted, Troels Petersen, Ivone Jakasa, Sanja Kezic, Jacob P Thyssen

Abstract

BACKGROUND: It is unknown whether skin biomarkers collected in infancy can predict the onset of atopic dermatitis (AD) and be used in future prevention trials to identify children at risk.

OBJECTIVES: This study sought to examine whether skin biomarkers can predict AD during the first 2 years of life.

METHODS: This study enrolled 300 term and 150 preterm children at birth and followed for AD until the age of 2 years. Skin tape strips were collected at 0 to 3 days and 2 months of age and analyzed for selected immune and barrier biomarkers. Hazard ratio (HR) with 95% confidence interval (CI) using Cox regression was calculated for the risk of AD.

RESULTS: The 2-year prevalence of AD was 34.6% (99 of 286) and 21.2% (25 of 118) among term and preterm children, respectively. Skin biomarkers collected at birth did not predict AD. Elevated thymus- and activation-regulated chemokine/C-C motif chemokine ligand 17 -levels collected at 2 months of age increased the overall risk of AD (HR: 2.11; 95% CI: 1.36-3.26; P = .0008) and moderate-to-severe AD (HR: 4.97; 95% CI: 2.09-11.80; P = .0003). IL-8 and IL-18 predicted moderate-to-severe AD. Low filaggrin degradation product levels increased the risk of AD (HR: 2.04; 95% CI: 1.32-3.15; P = .001). Elevated biomarker levels at 2 months predicted AD at other skin sites and many months after collection.

CONCLUSIONS: This study showed that noninvasively collected skin biomarkers of barrier and immune pathways can precede the onset of AD.

Original language	English
Journal	The Journal of allergy and clinical immunology
Pages (from-to)	epub
ISSN	0091-6749
DOIs	https://doi.org/10.1016/j.jaci.2022.11.023
Publication status	E-pub ahead of print - 23 Dec 2022

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10.1016/j.jaci.2022.11.023

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Halling, A-S., Rinnov, M. R., Ruge, I. F., Gerner, T., Ravn, N. H., Knudgaard, M. H., Trautner, S., Loft, N., Skov, L., Thomsen, S. F., Egeberg, A., Guttman-Yassky, E., Rosted, A. L. L., Petersen, T., Jakasa, I., Kezic, S., & Thyssen, J. P. (2022). Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis. The Journal of allergy and clinical immunology, epub. https://doi.org/10.1016/j.jaci.2022.11.023

Halling, A-S , Rinnov, MR, Ruge, IF, Gerner, T , Ravn, NH, Knudgaard, MH, Trautner, S , Loft, N , Skov, L , Thomsen, SF , Egeberg, A, Guttman-Yassky, E, Rosted, ALL, Petersen, T, Jakasa, I, Kezic, S & Thyssen, JP 2022, 'Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis', The Journal of allergy and clinical immunology, pp. epub. https://doi.org/10.1016/j.jaci.2022.11.023

@article{9422babf87f6443b88d43a12839cc497,

title = "Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis",

abstract = "BACKGROUND: It is unknown whether skin biomarkers collected in infancy can predict the onset of atopic dermatitis (AD) and be used in future prevention trials to identify children at risk.OBJECTIVES: This study sought to examine whether skin biomarkers can predict AD during the first 2 years of life.METHODS: This study enrolled 300 term and 150 preterm children at birth and followed for AD until the age of 2 years. Skin tape strips were collected at 0 to 3 days and 2 months of age and analyzed for selected immune and barrier biomarkers. Hazard ratio (HR) with 95% confidence interval (CI) using Cox regression was calculated for the risk of AD.RESULTS: The 2-year prevalence of AD was 34.6% (99 of 286) and 21.2% (25 of 118) among term and preterm children, respectively. Skin biomarkers collected at birth did not predict AD. Elevated thymus- and activation-regulated chemokine/C-C motif chemokine ligand 17 -levels collected at 2 months of age increased the overall risk of AD (HR: 2.11; 95% CI: 1.36-3.26; P = .0008) and moderate-to-severe AD (HR: 4.97; 95% CI: 2.09-11.80; P = .0003). IL-8 and IL-18 predicted moderate-to-severe AD. Low filaggrin degradation product levels increased the risk of AD (HR: 2.04; 95% CI: 1.32-3.15; P = .001). Elevated biomarker levels at 2 months predicted AD at other skin sites and many months after collection.CONCLUSIONS: This study showed that noninvasively collected skin biomarkers of barrier and immune pathways can precede the onset of AD.",

author = "Anne-Sofie Halling and Rinnov, {Maria Rasmussen} and Ruge, {Iben Frier} and Trine Gerner and Ravn, {Nina Haarup} and Knudgaard, {Mette Hjorslev} and Simon Trautner and Nikolai Loft and Lone Skov and Thomsen, {Simon F} and Alexander Egeberg and Emma Guttman-Yassky and Rosted, {Aske L L} and Troels Petersen and Ivone Jakasa and Sanja Kezic and Thyssen, {Jacob P}",

note = "Copyright {\textcopyright} 2022. Published by Elsevier Inc.",

year = "2022",

month = dec,

day = "23",

doi = "10.1016/j.jaci.2022.11.023",

language = "English",

pages = "epub",

journal = "The Journal of allergy and clinical immunology",

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TY - JOUR

T1 - Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis

AU - Halling, Anne-Sofie

AU - Rinnov, Maria Rasmussen

AU - Ruge, Iben Frier

AU - Gerner, Trine

AU - Ravn, Nina Haarup

AU - Knudgaard, Mette Hjorslev

AU - Trautner, Simon

AU - Loft, Nikolai

AU - Skov, Lone

AU - Thomsen, Simon F

AU - Egeberg, Alexander

AU - Guttman-Yassky, Emma

AU - Rosted, Aske L L

AU - Petersen, Troels

AU - Jakasa, Ivone

AU - Kezic, Sanja

AU - Thyssen, Jacob P

PY - 2022/12/23

Y1 - 2022/12/23

N2 - BACKGROUND: It is unknown whether skin biomarkers collected in infancy can predict the onset of atopic dermatitis (AD) and be used in future prevention trials to identify children at risk.OBJECTIVES: This study sought to examine whether skin biomarkers can predict AD during the first 2 years of life.METHODS: This study enrolled 300 term and 150 preterm children at birth and followed for AD until the age of 2 years. Skin tape strips were collected at 0 to 3 days and 2 months of age and analyzed for selected immune and barrier biomarkers. Hazard ratio (HR) with 95% confidence interval (CI) using Cox regression was calculated for the risk of AD.RESULTS: The 2-year prevalence of AD was 34.6% (99 of 286) and 21.2% (25 of 118) among term and preterm children, respectively. Skin biomarkers collected at birth did not predict AD. Elevated thymus- and activation-regulated chemokine/C-C motif chemokine ligand 17 -levels collected at 2 months of age increased the overall risk of AD (HR: 2.11; 95% CI: 1.36-3.26; P = .0008) and moderate-to-severe AD (HR: 4.97; 95% CI: 2.09-11.80; P = .0003). IL-8 and IL-18 predicted moderate-to-severe AD. Low filaggrin degradation product levels increased the risk of AD (HR: 2.04; 95% CI: 1.32-3.15; P = .001). Elevated biomarker levels at 2 months predicted AD at other skin sites and many months after collection.CONCLUSIONS: This study showed that noninvasively collected skin biomarkers of barrier and immune pathways can precede the onset of AD.

AB - BACKGROUND: It is unknown whether skin biomarkers collected in infancy can predict the onset of atopic dermatitis (AD) and be used in future prevention trials to identify children at risk.OBJECTIVES: This study sought to examine whether skin biomarkers can predict AD during the first 2 years of life.METHODS: This study enrolled 300 term and 150 preterm children at birth and followed for AD until the age of 2 years. Skin tape strips were collected at 0 to 3 days and 2 months of age and analyzed for selected immune and barrier biomarkers. Hazard ratio (HR) with 95% confidence interval (CI) using Cox regression was calculated for the risk of AD.RESULTS: The 2-year prevalence of AD was 34.6% (99 of 286) and 21.2% (25 of 118) among term and preterm children, respectively. Skin biomarkers collected at birth did not predict AD. Elevated thymus- and activation-regulated chemokine/C-C motif chemokine ligand 17 -levels collected at 2 months of age increased the overall risk of AD (HR: 2.11; 95% CI: 1.36-3.26; P = .0008) and moderate-to-severe AD (HR: 4.97; 95% CI: 2.09-11.80; P = .0003). IL-8 and IL-18 predicted moderate-to-severe AD. Low filaggrin degradation product levels increased the risk of AD (HR: 2.04; 95% CI: 1.32-3.15; P = .001). Elevated biomarker levels at 2 months predicted AD at other skin sites and many months after collection.CONCLUSIONS: This study showed that noninvasively collected skin biomarkers of barrier and immune pathways can precede the onset of AD.

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U2 - 10.1016/j.jaci.2022.11.023

DO - 10.1016/j.jaci.2022.11.023

M3 - Journal article

C2 - 36572354

SP - epub

JO - The Journal of allergy and clinical immunology

JF - The Journal of allergy and clinical immunology

SN - 0091-6749

ER -

Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis

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