Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Organ transplant recipients express enhanced skin autofluorescence and pigmentation at skin cancer sites

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Repeated treatments with ingenol mebutate for prophylaxis of UV-induced squamous cell carcinoma in hairless mice

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Sun behaviour and personal UVR exposure among Europeans on short term holidays

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

IMPORTANCE: Ultraviolet radiation (UVR)-induced skin cancers varies among organ transplant recipients (OTRs). To improve individual risk assessment of skin cancer, objectively quantified skin photodamage is needed.

OBJECTIVES: We measured personal UVR-exposure dose in OTRs and assessed the relation between individual UVR exposure, skin cancer and objectively measured photodamage in terms of skin autofluorescence, pigmentation, and black light-evaluated solar lentigines.

MATERIALS AND METHODS: Danish OTRs with (n=15) and without a history of skin cancer (n=15) kept sun diaries from May to September and wore personal dosimeters recording time-stamped UVR doses in standard erythema doses (SED). Photodamage was quantified as skin autofluorescence with excitation at 370nm (F370) and 430nm (F430), skin pigmentation (pigment protection factor, PPF), and black light-evaluated solar lentigines.

RESULTS: OTRs with skin cancer received a higher UVR dose than OTRs without skin cancer (median 116 SED vs. 67 SED, p=0.07) and UVR exposure doses were correlated with increased PPF (p=0.052) and F370 on the shoulder (F370shoulder) (p=0.04). We found that skin cancer was associated with F370shoulder (OR 10.53, CI 3.3-31,938; p=0.018) and time since transplantation (OR 1.34, CI 0.95-1.91, p=0.097). A cut-off at 7.2 arbitrary units, 89% of OTRs with skin cancer had F370shoulder values above 7.2 arbitrary units and F370shoulder was additionally related to patient age (p=0.09) and black light-evaluated solar lentigines (p=0.04).

CONCLUSION: F370 autofluorescence indicates objectively measured photodamage and may be used for individual risk assessment of skin cancer development in OTRs.

Original languageEnglish
JournalJournal of Photochemistry and Photobiology B: Biology
Volume178
Pages (from-to)577-583
Number of pages7
ISSN1011-1344
DOIs
Publication statusPublished - Jan 2018

    Research areas

  • Adult, Aged, Female, Humans, Lentigo/etiology, Luminescent Measurements, Male, Middle Aged, Odds Ratio, Organ Transplantation, Seasons, Skin/chemistry, Skin Neoplasms/etiology, Skin Pigmentation/radiation effects, Transplant Recipients, Ultraviolet Rays

ID: 56142385