Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Skin autofluorescence is associated with arterial stiffness and insulin level in endurance runners and healthy controls - Effects of aging and endurance exercise

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Maintenance of muscle strength following a one-year resistance training program in older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Perceived stress and dementia: Results from the Copenhagen city heart study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Inflammation, non-endothelial dependent coronary microvascular function and diastolic function-Are they linked?

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-Term Exposure to Air Pollution and Incidence of Myocardial Infarction: A Danish Nurse Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Life-long regular endurance exercise yields positive effects on cardiovascular and metabolic function, disease and mortality rate. Glycation may be a major mechanism behind age-related diseases. However, it remains unknown if skin autofluorescence (SAF), which reflects glycation, is related to arterial and metabolic function in life-long endurance runners and sedentary controls.

METHODS: Healthy elderly men: 15 life-long endurance runners (OT) (64±4years) and 12 old untrained (OU) (66±4years), and healthy young men; ten young athletes (YT) (26±4years) matched to OT for running distance, and 12 young untrained (YU) (24±3years) were recruited. Endothelial function (reactive hyperemia index, RHI) and arterial stiffness (augmentation index, AI@75 and AI) were measured by an operator-independent PAT 2000. SAF was non-invasively determined using an autofluorescence spectrometer.

RESULTS: For AI@75 there was an effect of age (p<0.0001), but not training (p=0.71). There was an interaction for endothelial function (p<0.05): YT had higher RHI than YU (p<0.05) and OU (p<0.01). SAF was associated with arterial stiffness (r2=0.57, p<0.001), insulin and HOMA-index levels after age correction (both r2=0.19, p<0.05).

CONCLUSIONS: To our knowledge, these are the first data to show that skin autofluorescence (SAF) is linked to human arterial stiffness and insulin resistance in well-trained elderly and young men as well as sedentary controls. SAF may in the future be a helpful tool to predict vascular and metabolic dysfunction (early signs of aging and pathology). Surprisingly, endurance running only had modest effects on cardiovascular function compared to lean healthy controls.

Original languageEnglish
JournalExperimental Gerontology
Volume91
Pages (from-to)9-14
Number of pages6
ISSN0531-5565
DOIs
Publication statusPublished - May 2017

    Research areas

  • Adult, Aged, Aging, Athletes, Biomarkers, Case-Control Studies, Denmark, Exercise Tolerance, Fluorescence, Glycation End Products, Advanced, Healthy Volunteers, Humans, Insulins, Linear Models, Male, Middle Aged, Reference Values, Running, Skin, Vascular Stiffness, Young Adult, Journal Article, Research Support, Non-U.S. Gov't

ID: 52333917