Skeletal muscle signaling and the heart rate and blood pressure response to exercise: insight from heart rate pacing during exercise with a trained and a deconditioned muscle group

Stefan P Mortensen; Jesper H Svendsen; Mads Ersbøll; Ylva Hellsten; Niels H Secher; Bengt Saltin

doi:10.1161/HYPERTENSIONAHA.111.00328

Skeletal muscle signaling and the heart rate and blood pressure response to exercise: insight from heart rate pacing during exercise with a trained and a deconditioned muscle group

Stefan P Mortensen, Jesper H Svendsen, Mads Ersbøll, Ylva Hellsten, Niels H Secher, Bengt Saltin

28 Citations (Scopus)

Abstract

Endurance training lowers heart rate and blood pressure responses to exercise, but the mechanisms and consequences remain unclear. To determine the role of skeletal muscle for the cardioventilatory response to exercise, 8 healthy young men were studied before and after 5 weeks of 1-legged knee-extensor training and 2 weeks of deconditioning of the other leg (leg cast). Hemodynamics and muscle interstitial nucleotides were determined during exercise with the (1) deconditioned leg, (2) trained leg, and (3) trained leg with atrial pacing to the heart rate obtained with the deconditioned leg. Heart rate was ≈ 15 bpm lower during exercise with the trained leg (P

Original language	English
Journal	Hypertension
Volume	61
Issue number	5
Pages (from-to)	1126-33
Number of pages	8
ISSN	0194-911X
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.111.00328
Publication status	Published - May 2013

Keywords

Adenosine Triphosphate
Adult
Blood Pressure
Cardiac Output
Exercise
Heart Rate
Humans
Hydrogen-Ion Concentration
Lactates
Leg
Male
Muscle, Skeletal
Norepinephrine
Physical Endurance
Potassium
Pulmonary Wedge Pressure
Stroke Volume

Access to Document

10.1161/HYPERTENSIONAHA.111.00328

Cite this

Skeletal muscle signaling and the heart rate and blood pressure response to exercise: insight from heart rate pacing during exercise with a trained and a deconditioned muscle group. / Mortensen, Stefan P; Svendsen, Jesper H ; Ersbøll, Mads et al.
In: Hypertension, Vol. 61, No. 5, 05.2013, p. 1126-33.

Research output: Contribution to journal › Journal article › Research › peer-review

@article{d5e1a08164274410aeb5d0e0d7bb8506,

title = "Skeletal muscle signaling and the heart rate and blood pressure response to exercise: insight from heart rate pacing during exercise with a trained and a deconditioned muscle group",

abstract = "Endurance training lowers heart rate and blood pressure responses to exercise, but the mechanisms and consequences remain unclear. To determine the role of skeletal muscle for the cardioventilatory response to exercise, 8 healthy young men were studied before and after 5 weeks of 1-legged knee-extensor training and 2 weeks of deconditioning of the other leg (leg cast). Hemodynamics and muscle interstitial nucleotides were determined during exercise with the (1) deconditioned leg, (2) trained leg, and (3) trained leg with atrial pacing to the heart rate obtained with the deconditioned leg. Heart rate was ≈ 15 bpm lower during exercise with the trained leg (P",

keywords = "Adenosine Triphosphate, Adult, Blood Pressure, Cardiac Output, Exercise, Heart Rate, Humans, Hydrogen-Ion Concentration, Lactates, Leg, Male, Muscle, Skeletal, Norepinephrine, Physical Endurance, Potassium, Pulmonary Wedge Pressure, Stroke Volume",

author = "Mortensen, {Stefan P} and Svendsen, {Jesper H} and Mads Ersb{\o}ll and Ylva Hellsten and Secher, {Niels H} and Bengt Saltin",

year = "2013",

month = may,

doi = "10.1161/HYPERTENSIONAHA.111.00328",

language = "English",

volume = "61",

pages = "1126--33",

journal = "Hypertension",

issn = "0194-911X",

publisher = "Lippincott Williams & Wilkins",

number = "5",

}

TY - JOUR

T1 - Skeletal muscle signaling and the heart rate and blood pressure response to exercise

T2 - insight from heart rate pacing during exercise with a trained and a deconditioned muscle group

AU - Mortensen, Stefan P

AU - Svendsen, Jesper H

AU - Ersbøll, Mads

AU - Hellsten, Ylva

AU - Secher, Niels H

AU - Saltin, Bengt

PY - 2013/5

Y1 - 2013/5

N2 - Endurance training lowers heart rate and blood pressure responses to exercise, but the mechanisms and consequences remain unclear. To determine the role of skeletal muscle for the cardioventilatory response to exercise, 8 healthy young men were studied before and after 5 weeks of 1-legged knee-extensor training and 2 weeks of deconditioning of the other leg (leg cast). Hemodynamics and muscle interstitial nucleotides were determined during exercise with the (1) deconditioned leg, (2) trained leg, and (3) trained leg with atrial pacing to the heart rate obtained with the deconditioned leg. Heart rate was ≈ 15 bpm lower during exercise with the trained leg (P

AB - Endurance training lowers heart rate and blood pressure responses to exercise, but the mechanisms and consequences remain unclear. To determine the role of skeletal muscle for the cardioventilatory response to exercise, 8 healthy young men were studied before and after 5 weeks of 1-legged knee-extensor training and 2 weeks of deconditioning of the other leg (leg cast). Hemodynamics and muscle interstitial nucleotides were determined during exercise with the (1) deconditioned leg, (2) trained leg, and (3) trained leg with atrial pacing to the heart rate obtained with the deconditioned leg. Heart rate was ≈ 15 bpm lower during exercise with the trained leg (P

KW - Adenosine Triphosphate

KW - Adult

KW - Blood Pressure

KW - Cardiac Output

KW - Exercise

KW - Heart Rate

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Lactates

KW - Leg

KW - Male

KW - Muscle, Skeletal

KW - Norepinephrine

KW - Physical Endurance

KW - Potassium

KW - Pulmonary Wedge Pressure

KW - Stroke Volume

U2 - 10.1161/HYPERTENSIONAHA.111.00328

DO - 10.1161/HYPERTENSIONAHA.111.00328

M3 - Journal article

C2 - 23478101

SN - 0194-911X

VL - 61

SP - 1126

EP - 1133

JO - Hypertension

JF - Hypertension

IS - 5

ER -

Skeletal muscle signaling and the heart rate and blood pressure response to exercise: insight from heart rate pacing during exercise with a trained and a deconditioned muscle group

Abstract

Keywords

Access to Document

Fingerprint

Cite this