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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Single-embryo transfer implies quality of care in reproductive medicine

Research output: Contribution to journalReviewpeer-review

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This review appraises evidence on the difference between single- and double-embryo transfer (SET, DET) in assisted reproductive technology (ART) regarding the four healthcare quality dimensions most important to fertility patients and doctors. Regarding safety, not only does DET create the uncontested perinatal risks of twin pregnancies, but compelling evidence has added that singleton pregnancies after a vanishing twin also have poorer perinatal outcomes. SET is as effective as DET, as shown by meta-analyses of randomized controlled trials, comparing two cycles of SET versus DET and shown by cumulative live birth rates of entire ART trajectories of up to six cycles. Proposing SET, which is safer than DET and as effective, as the gold standard is not irreconcilable with patient-centred care if patients are thoroughly informed on the reasoning behind the proposition and welcomed to challenge whether it fits their personal values. The cost-efficiency of SET is clearly higher, which has even induced certain countries to start reimbursing ART on the condition that SET is used. In conclusion, SET should be the gold standard offered to all patients. The question is not whether to apply SET but how to apply it in terms of patient selection, patient-centred counselling and coverage of treatment.

Original languageEnglish
JournalReproductive BioMedicine Online
Volume45
Issue number5
Pages (from-to)899-905
Number of pages7
ISSN1472-6483
DOIs
Publication statusPublished - Nov 2022

Bibliographical note

Copyright © 2022. Published by Elsevier Ltd.

    Research areas

  • DEET, Embryo Transfer/methods, Female, Fertilization in Vitro, Humans, Pregnancy, Pregnancy Rate, Quality of Health Care, Reproductive Medicine, Quality, Reproductive medicine, Single-embryo transfer (SET)

ID: 80258678