Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Single- vs. double-dose gadolinium contrast in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in knee osteoarthritis: is dose reduction possible on 3-T MRI?

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Grading lumbar disc degeneration: a comparison between low- and high-field MRI

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The effects of rotation on radiological parameters in the spine

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The efficacy of using computer-aided detection (CAD) for detection of breast cancer in mammography screening: a systematic review

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. New section editor: Cardiac Imaging

    Research output: Contribution to journalJournal articleCommunication

  5. Arterial spin labeling: a technical overview

    Research output: Contribution to journalReviewResearchpeer-review

  1. Imaging of Common Rheumatic Joint Diseases Affecting the Upper Limbs

    Research output: Contribution to journalReviewResearchpeer-review

  2. Early occupational intervention for people with low back pain in physically demanding jobs: A randomized clinical trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Inflammation and Hypervascularization in a Large Animal Model of Knee Osteoarthritis: Imaging with Pathohistologic Correlation

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Reduction in gadolinium (Gd) contrast agents is wanted due to the uncertainty of the potential side effects.

PURPOSE: To investigate whether it is possible to reduce the contrast dose from conventional double dose to single dose when increasing the field strength from 1.5-T to 3-T for separating early cartilage degeneration from healthy cartilage, assessed by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC).

MATERIAL AND METHODS: Nine patients with knee osteoarthritis (OA), Kellgren-Lawrence grade (KLG) 1-4, were recruited from an ongoing weight loss cohort study. dGEMRIC was performed at 3-T using single (0.1 mmoI/kg) and double (0.2 mmoI/kg) doses of intravenous (i.v.) Gd-DTPA2-. Regions of interest (ROls) were drawn around the posterior weight-bearing femoral knee cartilage in lateral and medial compartments. In five medial compartments ROIs could not be drawn due to severe degeneration of cartilage. T1-relaxation times were compared to previously published values from 1.5-T and to non-contrast values from 3-T.

RESULTS: Mean dGEMRIC T1-relaxation time in the lateral compartment was 769 ms for single dose vs. 561 ms for double dose ( P < 0.0001); and 685 ms for single dose vs. 454 ms for double dose ( P = 0.004) in the medial compartment.

CONCLUSION: We found a dose-response relationship between single and double doses of Gd-DTPA2- using 3-T in knee OA patients, similar to the findings at 1.5-T. Compared to the T1-relaxation time at 3-T without contrast (1240 ms), this further separation between OA and normal cartilage indicates that "single dose" dGEMRIC could be sufficient for cartilage health assessment at 3-T.

Original languageEnglish
JournalActa Radiologica
Volume60
Issue number6
Pages (from-to)749-754
Number of pages6
ISSN0284-1851
DOIs
Publication statusPublished - Jun 2019

    Research areas

  • Aged, Cartilage, Articular/diagnostic imaging, Cohort Studies, Contrast Media/administration & dosage, Female, Gadolinium/administration & dosage, Humans, Image Enhancement/methods, Knee Joint/diagnostic imaging, Magnetic Resonance Imaging/methods, Middle Aged, Osteoarthritis, Knee/diagnostic imaging, Radiation Dosage

ID: 57855159