Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy–Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Soluble Markers of Interleukin 1 Activation as Predictors of First-Time Myocardial Infarction in HIV-Infected Individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Increased risk of anemia, neutropenia and thrombocytopenia in people with HIV and well-controlled viral replication

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Mortality and admission to intensive care units after febrile neutropenia in patients with cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Uptake and Discontinuation of Integrase Inhibitors (INSTIs) in a Large Cohort Setting

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Lymphopenia and neutropenia are associated with subsequent incident proteinuria in Danish patients with systemic lupus erythematosus

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cutaneous leishmaniasis with secondary mucosal disease in a traveller due to Leishmania (Viannia) braziliensis

    Research output: Contribution to journalJournal articleResearchpeer-review

  • INSIGHT START Study Group
View graph of relations

The impact of variation in host genetics on replication of HIV-1 in demographically diverse populations remains uncertain. Here, we perform a genome-wide screen for associations of single nucleotide polymorphisms (SNP) to viral load (VL) in antiretroviral therapy-naïve participants (n=2,440) with varying demographics from the Strategic Timing of AntiRetroviral Treatment (START) trial. Associations were assessed using genotypic data generated by a customized SNP array, imputed human leukocyte antigen (HLA) alleles and multiple linear regression. Genome-wide significant associations between SNPs and VL were observed in the major histocompatibility complex (MHC) class I region with effect sizes ranging between 0.14-0.39 log10 VL. Supporting the SNP findings, we identified several HLA alleles significantly associated with VL, extending prior observations that the MHC I region is a major host determinant of HIV-1 control with shared genetic variants across diverse populations and underscoring the limitations of GWAS being merely a screening tool.

Original languageEnglish
JournalThe Journal of infectious diseases
Pages (from-to)1325
Number of pages1,334
ISSN0022-1899
DOIs
Publication statusPublished - 3 Sep 2019

ID: 57419112