Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance

Steen Larsen, Nis Ottesen Stride, Martin Hey-Mogensen, Christina Hansen, Lia E Bang, Henning Bundgaard, Lars B Nielsen, Jørn Wulff Helge, Flemming Dela

150 Citations (Scopus)

Abstract

Glucose tolerance and skeletal muscle coenzyme Q(10) (Q(10)) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9).
Original languageEnglish
JournalJournal of the American College of Cardiology
Volume61
Issue number1
Pages (from-to)44-53
Number of pages10
ISSN0735-1097
DOIs
Publication statusPublished - 8 Jan 2013

Keywords

  • Blood Glucose
  • Case-Control Studies
  • Cell Respiration
  • Electron Transport
  • Electron Transport Complex I
  • Electron Transport Complex II
  • Glucose Intolerance
  • Glucose Tolerance Test
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Insulin Resistance
  • Male
  • Middle Aged
  • Mitochondria, Muscle
  • Muscle Fibers, Skeletal
  • Muscle, Skeletal
  • Oxidative Phosphorylation
  • Simvastatin
  • Ubiquinone

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