Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Simple cardiovascular risk stratification by replacing total serum cholesterol with anthropometric measures: The MORGAM prospective cohort project

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Follow-up after abnormal cervical cancer screening in immigrants compared with Danish-born women - A nationwide register study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Participation in recreational activities varies with socioeconomic position and is associated with self-rated health and well-being

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Physical activity, self-rated fitness and stress among 55,185 men and women in the Danish Capital Region Health survey 2017

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Left atrial contractile strain predicts recurrence of atrial tachyarrhythmia after catheter ablation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Global and regional wall motion abnormalities and incident heart failure in the general population

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Advanced heart failure: guideline-directed medical therapy, diuretics, inotropes, and palliative care

    Research output: Contribution to journalReviewResearchpeer-review

View graph of relations

To assess whether anthropometric measures (body mass index [BMI], waist-hip ratio [WHR], and estimated fat mass [EFM]) are independently associated with major adverse cardiovascular events (MACE), and to assess their added prognostic value compared with serum total-cholesterol. The study population comprised 109,509 individuals (53% men) from the MORGAM-Project, aged 19-97 years, without established cardiovascular disease, and not on antihypertensive treatment. While BMI was reported in all, WHR and EFM were reported in ∼52,000 participants. Prognostic importance of anthropometric measurements and total-cholesterol was evaluated using adjusted Cox proportional-hazards regression, logistic regression, area under the receiver-operating-characteristic curve (AUCROC), and net reclassification improvement (NRI). The primary endpoint was MACE, a composite of stroke, myocardial infarction, or death from coronary heart disease. Age interacted significantly with anthropometric measures and total-cholesterol on MACE (P ≤ 0.003), and therefore age-stratified analyses (<50 versus ≥ 50 years) were performed. BMI, WHR, EFM, and total-cholesterol were independently associated with MACE (P ≤ 0.003) and resulted in significantly positive NRI when added to age, sex, smoking status, and systolic blood pressure. Only total-cholesterol increased discrimination ability (AUCROC difference; P < 0.001). In subjects < 50 years, the prediction model with total-cholesterol was superior to the model including BMI, but not superior to models containing WHR or EFM, while in those ≥ 50 years, the model with total-cholesterol was superior to all models containing anthropometric variables, whether assessed individually or combined. We found a potential role for replacing total-cholesterol with anthropometric measures for MACE-prediction among individuals < 50 years when laboratory measurements are unavailable, but not among those ≥ 50 years.

Original languageEnglish
Article number101700
JournalPreventive Medicine Reports
Volume26
Pages (from-to)101700
ISSN2211-3355
DOIs
Publication statusPublished - Apr 2022

Bibliographical note

© 2022 The Author(s).

ID: 74271747