Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Sildenafil does not influence hepatic venous pressure gradient in patients with cirrhosis

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ethnic differences in inflammatory bowel disease: Results from the United Kingdom inception cohort epidemiology study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Development and predictive validity of the cirrhosis-associated ascites symptom scale: A cohort study of 103 patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Epidemiology of inflammatory bowel disease in racial and ethnic migrant groups

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Challenges in conducting paediatric trials with off-patent drugs

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Safety of High-Volume Plasmapheresis in Children With Acute Liver Failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Medication errors in residential facilities based on Danish Poison Information Center inquiries

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

AIM: To investigate if sildenafil increases splanchnic blood flow and changes the hepatic venous pressure gradient (HVPG) in patients with cirrhosis. Phosphodiesterase type-5 inhibitors are valuable in the treatment of erectile dysfunction and pulmonary hypertension in patients with end-stage liver disease. However, the effect of phosphodiesterase type-5 inhibitors on splanchnic blood flow and portal hypertension remains essentially unknown.

METHODS: Ten patients with biopsy proven cirrhosis (five females/five males, mean age 54 +/- 8 years) and an HVPG above 12 mmHg were studied after informed consent. Measurement of splanchnic blood flow and the HVPG during liver vein catheterization were done before and 80 min after oral administration of 50 mg sildenafil. Blood flow was estimated by use of indocyanine green clearance technique and Fick's principle, with correction for non-steady state.

RESULTS: The plasma concentration of sildenafil was 222 +/- 136 ng/mL 80 min after administration. Mean arterial blood pressure decreased from 77 +/- 7 mmHg to 66 +/- 12 mmHg, P = 0.003, while the splanchnic blood flow and oxygen consumption remained unchanged at 1.14 +/- 0.71 L/min and 2.3 +/- 0.6 mmol/min, respectively. Also the HVPG remained unchanged (18 +/- 2 mmHg vs 16 +/- 2 mmHg) with individual changes ranging from -8 mmHg to +2 mmHg. In seven patients, HVPG decreased and in three it increased.

CONCLUSION: In spite of arterial blood pressure decreases 80 min after administration of the phosphodiesterase type-5 inhibitor sildenafil, the present study could not demonstrate any clinical relevant influence on splanichnic blood flow, oxygen consumption or the HVPG.

Original languageEnglish
JournalWorld Journal of Gastroenterology
Volume14
Issue number40
Pages (from-to)6208-12
Number of pages5
ISSN1007-9327
Publication statusPublished - 28 Oct 2008

    Research areas

  • Administration, Oral, Adult, Female, Humans, Hypertension, Portal, Liver Cirrhosis, Male, Middle Aged, Oxygen Consumption, Phosphodiesterase 5 Inhibitors, Phosphodiesterase Inhibitors, Piperazines, Purines, Sildenafil Citrate, Splanchnic Circulation, Sulfones, Time Factors, Treatment Outcome, Vasodilator Agents, Venous Pressure, Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't

ID: 49582132