Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Significance of the S100A4 protein in psoriasis

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Filaggrin Expression and Processing Deficiencies Impair Corneocyte Surface Texture and Stiffness in Mice

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells’ Type 1 Interferon Response

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Racial/Ethnic Differences in Incidence and Persistence of Childhood Atopic Dermatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Incidence and Risk of Inflammatory Bowel Disease in Patients with Psoriasis-A Nationwide 20-Year Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. SATB1 in Malignant T Cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prenatal, infantile, and childhood tobacco exposure and risk of pediatric psoriasis in the Danish National Birth Cohort offspring

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Treatment of Widespread Eosinophilic Cellulitis (Wells' Syndrome) with Benralizumab

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Clinical Relevance of Skin Pain in Atopic Dermatitis

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Impact of Atopic Dermatitis Lesion Location on Quality of Life in Adult Patients in a Real-world Study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
The S100A4 protein is reported as a pivotal player in the tumor microenvironment with a metastasis-promoting function. Moreover, the upregulation of S100A4 is found in other non-malignant human disorders as cardiac and pulmonary systems and rheumatoid arthritis. In this study, we investigated the expression and significance of S100A4 in psoriasis. We found significant upregulation of S100A4 in the dermis of psoriatic skin compared with normal skin. This pattern of S100A4 expression differs considerably from that of other S100 proteins, S100A7 and S100A8/9, with predominant expression in the epidermis of psoriasis. Furthermore, we revealed a massive release of the biologically active forms of S100A4 from psoriatic skin. Interestingly, we found stabilization (increase) of p53 in the basal layer of epidermis in close proximity to cells expressing S100A4. To examine the possible implication of S100A4 in the pathogenesis of psoriasis, we analyzed the effect of S100A4 blocking antibodies in a human psoriasis xenograft SCID mouse model and observed a significant reduction of the epidermal thickness and impairment in cell proliferation and dermal vascularization. In conclusion, we showed strong upregulation and release of S100A4 in the upper dermis of psoriatic skin and found evidence indicating that S100A4 might actively contribute to the pathogenesis of psoriasis.
Original languageEnglish
JournalThe Journal of investigative dermatology
Volume130
Issue number1
Pages (from-to)150-60
Number of pages11
DOIs
Publication statusPublished - 1 Jan 2010

ID: 32167618