Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo

Thuc Anh Ngo; Mads Achen Riemann; Niels-Henrik Holstein-Rathlou; Christian Torp-Pedersen; Lars Jørn Jensen

doi:10.1186/1472-6793-13-8

Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo

Thuc Anh Ngo
, Mads Achen Riemann
, Niels-Henrik Holstein-Rathlou
, Christian Torp-Pedersen
, Lars Jørn Jensen

19 Citations (Scopus)

Abstract

ATP-sensitive K⁺ channels (KATP channels), NO, prostaglandins, 20-HETE and L-type Ca²⁺ channels have all been suggested to be involved in oxygen sensing in skeletal muscle arterioles, but the role of the individual mechanisms remain controversial. We aimed to establish the importance of these mechanisms for oxygen sensing in arterioles in an in vivo model of metabolically active skeletal muscle. For this purpose we utilized the exteriorized cremaster muscle of anesthetized mice, in which the cremaster muscle was exposed to controlled perturbation of tissue PO₂.

Original language	English
Journal	B M C Physiology
Volume	13
Pages (from-to)	8
ISSN	1472-6793
DOIs	https://doi.org/10.1186/1472-6793-13-8
Publication status	Published - 2013

Keywords

Animals
Arterioles
Calcium Channels, L-Type
Cromakalim
Cytochrome P-450 Enzyme System
Glyburide
Hydroxyeicosatetraenoic Acids
KATP Channels
Male
Mice
Mice, Inbred C57BL
Muscle, Skeletal
Muscle, Smooth, Vascular
Nifedipine
Nitric Oxide Synthase
Oxygen
Vasoconstriction
Vasodilation

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10.1186/1472-6793-13-8

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title = "Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo",

abstract = "ATP-sensitive K⁺ channels (KATP channels), NO, prostaglandins, 20-HETE and L-type Ca²⁺ channels have all been suggested to be involved in oxygen sensing in skeletal muscle arterioles, but the role of the individual mechanisms remain controversial. We aimed to establish the importance of these mechanisms for oxygen sensing in arterioles in an in vivo model of metabolically active skeletal muscle. For this purpose we utilized the exteriorized cremaster muscle of anesthetized mice, in which the cremaster muscle was exposed to controlled perturbation of tissue PO₂.",

keywords = "Animals, Arterioles, Calcium Channels, L-Type, Cromakalim, Cytochrome P-450 Enzyme System, Glyburide, Hydroxyeicosatetraenoic Acids, KATP Channels, Male, Mice, Mice, Inbred C57BL, Muscle, Skeletal, Muscle, Smooth, Vascular, Nifedipine, Nitric Oxide Synthase, Oxygen, Vasoconstriction, Vasodilation",

author = "Ngo, \{Thuc Anh\} and Riemann, \{Mads Achen\} and Niels-Henrik Holstein-Rathlou and Christian Torp-Pedersen and Jensen, \{Lars J{\o}rn\}",

year = "2013",

doi = "10.1186/1472-6793-13-8",

language = "English",

volume = "13",

pages = "8",

journal = "B M C Physiology",

issn = "1472-6793",

publisher = "BioMed Central Ltd",

}

TY - JOUR

T1 - Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo

AU - Ngo, Thuc Anh

AU - Riemann, Mads Achen

AU - Holstein-Rathlou, Niels-Henrik

AU - Torp-Pedersen, Christian

AU - Jensen, Lars Jørn

PY - 2013

Y1 - 2013

N2 - ATP-sensitive K⁺ channels (KATP channels), NO, prostaglandins, 20-HETE and L-type Ca²⁺ channels have all been suggested to be involved in oxygen sensing in skeletal muscle arterioles, but the role of the individual mechanisms remain controversial. We aimed to establish the importance of these mechanisms for oxygen sensing in arterioles in an in vivo model of metabolically active skeletal muscle. For this purpose we utilized the exteriorized cremaster muscle of anesthetized mice, in which the cremaster muscle was exposed to controlled perturbation of tissue PO₂.

AB - ATP-sensitive K⁺ channels (KATP channels), NO, prostaglandins, 20-HETE and L-type Ca²⁺ channels have all been suggested to be involved in oxygen sensing in skeletal muscle arterioles, but the role of the individual mechanisms remain controversial. We aimed to establish the importance of these mechanisms for oxygen sensing in arterioles in an in vivo model of metabolically active skeletal muscle. For this purpose we utilized the exteriorized cremaster muscle of anesthetized mice, in which the cremaster muscle was exposed to controlled perturbation of tissue PO₂.

KW - Animals

KW - Arterioles

KW - Calcium Channels, L-Type

KW - Cromakalim

KW - Cytochrome P-450 Enzyme System

KW - Glyburide

KW - Hydroxyeicosatetraenoic Acids

KW - KATP Channels

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Muscle, Skeletal

KW - Muscle, Smooth, Vascular

KW - Nifedipine

KW - Nitric Oxide Synthase

KW - Oxygen

KW - Vasoconstriction

KW - Vasodilation

U2 - 10.1186/1472-6793-13-8

DO - 10.1186/1472-6793-13-8

M3 - Journal article

C2 - 23663730

SN - 1472-6793

VL - 13

SP - 8

JO - B M C Physiology

JF - B M C Physiology

ER -

Significance of K(ATP) channels, L-type Ca²⁺ channels and CYP450-4A enzymes in oxygen sensing in mouse cremaster muscle arterioles in vivo

Abstract

Keywords

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