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The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Shorter recall period for the thyroid-related patient-reported outcome measure ThyPRO did not change the accuracy as evaluated by repeated momentary measurements

Research output: Contribution to journalJournal articleResearchpeer-review


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Background The thyroid-related patient-reported outcome measure ThyPRO has become the gold standard for measuring thyroid-related quality of life and uses a 4-week recall period. The impact of the length of recall is unresolved. To minimize recall bias, the U.S. Food and Drug Administration has argued in favor of short recall periods or measures describing current states. We investigated whether a 1-week recall version of ThyPRO was less prone to recall bias than the original ThyPRO, using averaged momentary ThyPRO measurements as the hypothesized true mean of patients' symptoms. Methods Patients newly diagnosed with thyrotoxicosis were included (N=122). During a 28 days study period, participants answered momentary questions three times daily via a smartphone, weekly retrospective surveys with a 1-week recall period, and the original survey with a 4-week recall period on day 28. Twelve ThyPRO items from four multi-item scales were used. Mean momentary ratings for each scale were compared with recall ratings of 1-week and 4-week periods, respectively. Results Mean momentary ratings were highly correlated with retrospective ratings and remained rather constant when altering the reporting period from four to one week. We found consistently lower scores (i.e. better thyroid-related quality of life) on momentary ratings compared with retrospective ratings. Mean differences between momentary and retrospective ratings were similar for both recall periods. The original 4-week ThyPRO accurately summarized the mean of all 1-week ThyPROs. Conclusions Shortening the recall period of ThyPRO from four to one week was not associated with less recall bias within this subset of items. Nor did 1-week recall seem to compromise the accuracy of ThyPRO. Thus, either version of ThyPRO can be used in future studies.

Original languageEnglish
JournalThyroid : official journal of the American Thyroid Association
Publication statusE-pub ahead of print - 13 Jan 2020

ID: 59035876