Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men

V P Garcia; J D Mattos; J Mentzinger; P E C Leite; H N M Rocha; M O Campos; M P Rocha; D E Mansur; N H Secher; A C L Nóbrega; I A Fernandes; N G Rocha

doi:10.1590/1414-431X2022e12110

Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men

V P Garcia, J D Mattos, J Mentzinger, P E C Leite, H N M Rocha, M O Campos, M P Rocha, D E Mansur, N H Secher, A C L Nóbrega, I A Fernandes, N G Rocha

Department of Anaesthesiology

Abstract

In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix metalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.

Original language	English
Article number	e12110
Journal	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Volume	55
Pages (from-to)	1-6
Number of pages	6
ISSN	0100-879X
DOIs	https://doi.org/10.1590/1414-431X2022e12110
Publication status	Published - 2022

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Garcia, V. P., Mattos, J. D., Mentzinger, J., Leite, P. E. C., Rocha, H. N. M., Campos, M. O., Rocha, M. P., Mansur, D. E., Secher, N. H., Nóbrega, A. C. L., Fernandes, I. A., & Rocha, N. G. (2022). Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 55, 1-6. Article e12110. https://doi.org/10.1590/1414-431X2022e12110

Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men. / Garcia, V P; Mattos, J D; Mentzinger, J et al.
In: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, Vol. 55, e12110, 2022, p. 1-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Garcia, VP, Mattos, JD, Mentzinger, J, Leite, PEC, Rocha, HNM, Campos, MO, Rocha, MP, Mansur, DE, Secher, NH, Nóbrega, ACL, Fernandes, IA & Rocha, NG 2022, 'Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men', Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, vol. 55, e12110, pp. 1-6. https://doi.org/10.1590/1414-431X2022e12110

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title = "Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men",

abstract = "In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100\% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21\% O2) and 10-min hyperoxia trials (100\% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix metalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100\% oxygen may affect endothelial activation and vascular remodeling.",

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AU - Garcia, V P

AU - Mattos, J D

AU - Mentzinger, J

AU - Leite, P E C

AU - Rocha, H N M

AU - Campos, M O

AU - Rocha, M P

AU - Mansur, D E

AU - Secher, N H

AU - Nóbrega, A C L

AU - Fernandes, I A

AU - Rocha, N G

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N2 - In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix metalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.

AB - In preparation for tracheal intubation during induction of anesthesia, the patient may be ventilated with 100% oxygen. To investigate the impact of acute isocapnic hyperoxia on endothelial activation and vascular remodeling, ten healthy young men (24±3 years) were exposed to 5-min normoxia (21% O2) and 10-min hyperoxia trials (100% O2). During hyperoxia, intercellular adhesion molecules (ICAM-1) (hyperoxia: 4.16±0.85 vs normoxia: 3.51±0.84 ng/mL, P=0.04) and tissue inhibitor matrix metalloproteinase 1 (TIMP-1) (hyperoxia: 8.40±3.84 vs normoxia: 5.73±2.15 pg/mL, P=0.04) increased, whereas matrix metalloproteinase (MMP-9) activity (hyperoxia: 0.53±0.11 vs normoxia: 0.68±0.18 A.U., P=0.03) decreased compared to the normoxia trial. We concluded that even short exposure to 100% oxygen may affect endothelial activation and vascular remodeling.

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ER -

Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men

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