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Short erythropoietin-derived peptide enhances memory, improves long-term potentiation, and counteracts amyloid beta-induced pathology

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  1. Striking reduction in neurons and glial cells in anterior thalamic nuclei of older patients with Down syndrome

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  2. The total number of myelinated nerve fibers is reduced in corpus callosum in brains from patients with Alzheimer's disease

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  3. The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome

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  4. EEG correlates of visual short-term memory in older age vary with adult lifespan cognitive development

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  1. Retinal layer segmentation in rodent OCT images: Local intensity profiles & fully convolutional neural networks

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  2. Neurotrophic Effects of Vascular Endothelial Growth Factor B and Novel Mimetic Peptides on Neurons from the Central Nervous System

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  3. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

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  4. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

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  5. Towards automatic glaucoma assessment: An Encoder-decoder CNN for Retinal Layer Segmentation in Rodent OCT images

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Neurodegenerative disorders such as Alzheimer's disease (AD) are characterized by the irreversible neuronal loss and memory impairment, and current treatments are merely symptomatic. Erythropoietin (EPO) has been shown to possess neurotrophic, neuroprotective, anti-inflammatory, and memory-enhancing effects, which could be therapeutically beneficial in the different aspects of AD. However, the hematopoietic effect of EPO has hampered its potential as a neuroprotective and procognitive agent. In this study, we characterized a novel small peptide, NL100, derived from a conserved C-helix region of EPO. NL100 was shown to bind to the EPO receptor, induce neuritogenesis, and protect hippocampal neurons from oxidative- and Aβ25-35-induced neurodegeneration in vitro. Importantly, long-term NL100 treatment did not induce hematopoiesis, overcoming this challenge associated with EPO. Memory-enhancing effects were demonstrated after NL100 treatment in social recognition test for short-term memory, in both healthy rats and rats challenged centrally with Aβ25-35 peptide, and in the Morris water maze test for spatial memory. Moreover, NL100 was shown to reverse Aβ25-35-induced hippocampal degeneration and gliosis as well as pilocarpine-induced suppression of long-term potentiation in rats. In conclusion, NL100 is a novel EPO-derived nonhematopoietic peptide with neuroprotective and memory-enhancing effects and could therefore be a potential candidate for the development of new treatments for neurodegenerative disorders and dementia.

Original languageEnglish
JournalNeurobiology of Aging
Volume81
Pages (from-to)88-101
Number of pages14
ISSN0197-4580
DOIs
Publication statusPublished - Sep 2019

ID: 59292981