Short- and long-term effects of endurance training in patients with mitochondrial myopathy

T D Jeppesen, M Dunø, M Schwartz, T Krag, J Rafiq, F Wibrand, J Vissing

Abstract

BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.

METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations.

RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.

CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

Original languageEnglish
JournalEuropean Journal of Neurology
Volume16
Issue number12
Pages (from-to)1336-9
Number of pages4
ISSN1351-5101
DOIs
Publication statusPublished - Dec 2009

Keywords

  • Exercise Therapy/methods
  • Exercise Tolerance/physiology
  • Humans
  • Mitochondrial Myopathies/metabolism
  • Muscle, Skeletal/metabolism
  • Time

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