Short- and long-term effects of endurance training in patients with mitochondrial myopathy

T D Jeppesen; M Dunø; M Schwartz; T Krag; J Rafiq; F Wibrand; J Vissing

doi:10.1111/j.1468-1331.2009.02660.x

Short- and long-term effects of endurance training in patients with mitochondrial myopathy

T D Jeppesen, M Dunø, M Schwartz, T Krag, J Rafiq, F Wibrand, J Vissing

40 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.

METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations.

RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.

CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

Original language	English
Journal	European Journal of Neurology
Volume	16
Issue number	12
Pages (from-to)	1336-9
Number of pages	4
ISSN	1351-5101
DOIs	https://doi.org/10.1111/j.1468-1331.2009.02660.x
Publication status	Published - Dec 2009

Keywords

Exercise Therapy/methods
Exercise Tolerance/physiology
Humans
Mitochondrial Myopathies/metabolism
Muscle, Skeletal/metabolism
Time

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10.1111/j.1468-1331.2009.02660.x

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abstract = "BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations.RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.",

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T1 - Short- and long-term effects of endurance training in patients with mitochondrial myopathy

AU - Jeppesen, T D

AU - Dunø, M

AU - Schwartz, M

AU - Krag, T

AU - Rafiq, J

AU - Wibrand, F

AU - Vissing, J

PY - 2009/12

Y1 - 2009/12

N2 - BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations.RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

AB - BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations.METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations.RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle.CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.

KW - Exercise Therapy/methods

KW - Exercise Tolerance/physiology

KW - Humans

KW - Mitochondrial Myopathies/metabolism

KW - Muscle, Skeletal/metabolism

KW - Time

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JO - European Journal of Neurology

JF - European Journal of Neurology

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Short- and long-term effects of endurance training in patients with mitochondrial myopathy

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Keywords

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