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Shared heritability and functional enrichment across six solid cancers

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  1. Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

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  2. Infant airway microbiota and topical immune perturbations in the origins of childhood asthma

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  3. Publisher Correction: Shared heritability and functional enrichment across six solid cancers

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  4. Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

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  1. Risk of CIN2+ following a diagnosis of genital warts: a nationwide cohort study

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  2. Prevalence and risk factors of prolonged QT interval and electrocardiographic abnormalities in persons living with HIV

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Risk of breast cancer among women with benign ovarian tumors: a Danish nationwide cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Xia Jiang
  • Hilary K Finucane
  • Fredrick R Schumacher
  • Stephanie L Schmit
  • Jonathan P Tyrer
  • Younghun Han
  • Kyriaki Michailidou
  • Corina Lesseur
  • Karoline B Kuchenbaecker
  • Joe Dennis
  • David V Conti
  • Graham Casey
  • Mia M Gaudet
  • Jeroen R Huyghe
  • Demetrius Albanes
  • Melinda C Aldrich
  • Angeline S Andrew
  • Irene L Andrulis
  • Hoda Anton-Culver
  • Antonis C Antoniou
  • Natalia N Antonenkova
  • Susanne M Arnold
  • Kristan J Aronson
  • Banu K Arun
  • Elisa V Bandera
  • Rosa B Barkardottir
  • Daniel R Barnes
  • Jyotsna Batra
  • Matthias W Beckmann
  • Javier Benitez
  • Sara Benlloch
  • Andrew Berchuck
  • Sonja I Berndt
  • Heike Bickeböller
  • Stephanie A Bien
  • Carl Blomqvist
  • Stefania Boccia
  • Natalia V Bogdanova
  • Stig E Bojesen
  • Manjeet K Bolla
  • Hiltrud Brauch
  • Hermann Brenner
  • James D Brenton
  • Mark N Brook
  • Joan Brunet
  • Hans Brunnström
  • Daniel D Buchanan
  • Barbara Burwinkel
  • Ralf Butzow
  • Gabriella Cadoni
  • Trinidad Caldés
  • Maria A Caligo
  • Ian Campbell
  • Peter T Campbell
  • Géraldine Cancel-Tassin
  • Lisa Cannon-Albright
  • Daniele Campa
  • Neil Caporaso
  • André L Carvalho
  • Andrew T Chan
  • Jenny Chang-Claude
  • Stephen J Chanock
  • Chu Chen
  • David C Christiani
  • Kathleen B M Claes
  • Frank Claessens
  • Judith Clements
  • J Margriet Collée
  • Marcia Cruz Correa
  • Fergus J Couch
  • Angela Cox
  • Julie M Cunningham
  • Cezary Cybulski
  • Kamila Czene
  • Mary B Daly
  • Anna deFazio
  • Peter Devilee
  • Orland Diez
  • Manuela Gago-Dominguez
  • Jenny L Donovan
  • Thilo Dörk
  • Eric J Duell
  • Alison M Dunning
  • Miriam Dwek
  • Diana M Eccles
  • Christopher K Edlund
  • Digna R Velez Edwards
  • Carolina Ellberg
  • D Gareth Evans
  • Peter A Fasching
  • Robert L Ferris
  • Triantafillos Liloglou
  • Jane C Figueiredo
  • Olivia Fletcher
  • Renée T Fortner
  • Florentia Fostira
  • Silvia Franceschi
  • Eitan Friedman
  • Steven J Gallinger
  • Patricia A Ganz
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  • José A García-Sáenz
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  • Mark S Goldberg
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  • Ellen L Goode
  • Marc T Goodman
  • Gary Goodman
  • Kjell Grankvist
  • Mark H Greene
  • Henrik Gronberg
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  • Pascal Guénel
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  • Per Hall
  • Ute Hamann
  • Freddie C Hamdy
  • Robert J Hamilton
  • Jochen Hampe
  • Aage Haugen
  • Florian Heitz
  • Rolando Herrero
  • Peter Hillemanns
  • Michael Hoffmeister
  • Estrid Høgdall
  • Yun-Chul Hong
  • John L Hopper
  • Richard Houlston
  • Peter J Hulick
  • David J Hunter
  • David G Huntsman
  • Gregory Idos
  • Evgeny N Imyanitov
  • Sue Ann Ingles
  • Claudine Isaacs
  • Anna Jakubowska
  • Paul James
  • Mark A Jenkins
  • Mattias Johansson
  • Mikael Johansson
  • Esther M John
  • Amit D Joshi
  • Radka Kaneva
  • Beth Y Karlan
  • Linda E Kelemen
  • Tabea Kühl
  • Kay-Tee Khaw
  • Elza Khusnutdinova
  • Adam S Kibel
  • Lambertus A Kiemeney
  • Jeri Kim
  • Susanne K Kjaer
  • Julia A Knight
  • Manolis Kogevinas
  • Zsofia Kote-Jarai
  • Stella Koutros
  • Vessela N Kristensen
  • Jolanta Kupryjanczyk
  • Martin Lacko
  • Stephan Lam
  • Diether Lambrechts
  • Maria Teresa Landi
  • Philip Lazarus
  • Nhu D Le
  • Eunjung Lee
  • Flavio Lejbkowicz
  • Heinz-Josef Lenz
  • Goska Leslie
  • Davor Lessel
  • Jenny Lester
  • Douglas A Levine
  • Li Li
  • Christopher I Li
  • Annika Lindblom
  • Noralane M Lindor
  • Geoffrey Liu
  • Fotios Loupakis
  • Jan Lubiński
  • Lovise Maehle
  • Christiane Maier
  • Arto Mannermaa
  • Loic Le Marchand
  • Sara Margolin
  • Taymaa May
  • Lesley McGuffog
  • Alfons Meindl
  • Pooja Middha
  • Austin Miller
  • Roger L Milne
  • Robert J MacInnis
  • Francesmary Modugno
  • Marco Montagna
  • Victor Moreno
  • Kirsten B Moysich
  • Lorelei Mucci
  • Kenneth Muir
  • Anna Marie Mulligan
  • Katherine L Nathanson
  • David E Neal
  • Andrew R Ness
  • Susan L Neuhausen
  • Heli Nevanlinna
  • Polly A Newcomb
  • Lisa F Newcomb
  • Finn Cilius Nielsen
  • Liene Nikitina-Zake
  • Børge G Nordestgaard
  • Robert L Nussbaum
  • Kenneth Offit
  • Edith Olah
  • Ali Amin Al Olama
  • Olufunmilayo I Olopade
  • Andrew F Olshan
  • Håkan Olsson
  • Ana Osorio
  • Hardev Pandha
  • Jong Y Park
  • Nora Pashayan
  • Michael T Parsons
  • Tanja Pejovic
  • Kathryn L Penney
  • Wilbert H M Peters
  • Catherine M Phelan
  • Amanda I Phipps
  • Dijana Plaseska-Karanfilska
  • Miranda Pring
  • Darya Prokofyeva
  • Paolo Radice
  • Kari Stefansson
  • Susan J Ramus
  • Leon Raskin
  • Gad Rennert
  • Hedy S Rennert
  • Elizabeth J van Rensburg
  • Marjorie J Riggan
  • Harvey A Risch
  • Angela Risch
  • Monique J Roobol
  • Barry S Rosenstein
  • Mary Anne Rossing
  • Kim De Ruyck
  • Emmanouil Saloustros
  • Dale P Sandler
  • Elinor J Sawyer
  • Matthew B Schabath
  • Johanna Schleutker
  • Marjanka K Schmidt
  • V Wendy Setiawan
  • Hongbing Shen
  • Erin M Siegel
  • Weiva Sieh
  • Christian F Singer
  • Martha L Slattery
  • Karina Dalsgaard Sorensen
  • Melissa C Southey
  • Amanda B Spurdle
  • Janet L Stanford
  • Victoria L Stevens
  • Sebastian Stintzing
  • Jennifer Stone
  • Karin Sundfeldt
  • Rebecca Sutphen
  • Anthony J Swerdlow
  • Eloiza H Tajara
  • Catherine M Tangen
  • Adonina Tardon
  • Jack A Taylor
  • M Dawn Teare
  • Manuel R Teixeira
  • Mary Beth Terry
  • Kathryn L Terry
  • Stephen N Thibodeau
  • Mads Thomassen
  • Line Bjørge
  • Marc Tischkowitz
  • Amanda E Toland
  • Diana Torres
  • Paul A Townsend
  • Ruth C Travis
  • Nadine Tung
  • Shelley S Tworoger
  • Cornelia M Ulrich
  • Nawaid Usmani
  • Celine M Vachon
  • Els Van Nieuwenhuysen
  • Ana Vega
  • Miguel Elías Aguado-Barrera
  • Qin Wang
  • Penelope M Webb
  • Clarice R Weinberg
  • Stephanie Weinstein
  • Mark C Weissler
  • Jeffrey N Weitzel
  • Catharine M L West
  • Emily White
  • Alice S Whittemore
  • H-Erich Wichmann
  • Fredrik Wiklund
  • Robert Winqvist
  • Alicja Wolk
  • Penella Woll
  • Michael Woods
  • Anna H Wu
  • Xifeng Wu
  • Drakoulis Yannoukakos
  • Wei Zheng
  • Shanbeh Zienolddiny
  • Argyrios Ziogas
  • Kristin K Zorn
  • Jacqueline M Lane
  • Richa Saxena
  • Duncan Thomas
  • Rayjean J Hung
  • Brenda Diergaarde
  • James McKay
  • Ulrike Peters
  • Li Hsu
  • Montserrat García-Closas
  • Rosalind A Eeles
  • Georgia Chenevix-Trench
  • Paul J Brennan
  • Christopher A Haiman
  • Jacques Simard
  • Douglas F Easton
  • Stephen B Gruber
  • Paul D P Pharoah
  • Alkes L Price
  • Bogdan Pasaniuc
  • Christopher I Amos
  • Peter Kraft
  • Sara Lindström
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Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

Original languageEnglish
Article number431
JournalNature Communications
Volume10
Issue number1
Pages (from-to)431
ISSN2041-1723
DOIs
Publication statusPublished - 1 Dec 2019

    Research areas

  • Breast Neoplasms/diagnosis, Case-Control Studies, Colorectal Neoplasms/diagnosis, European Continental Ancestry Group, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Head and Neck Neoplasms/diagnosis, Humans, Inheritance Patterns, Lung Neoplasms/diagnosis, Male, Mental Disorders/ethnology, Neoplasm Proteins/genetics, Ovarian Neoplasms/diagnosis, Phenotype, Polymorphism, Single Nucleotide, Prostatic Neoplasms/diagnosis, Smoking/ethnology

ID: 56626231