Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Sexual function in a nationwide cohort of 2260 testicular cancer survivors after 17 years follow-up

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Fertility Potential is Impaired in Boys with Bilateral Ascending Testes

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Reply by Authors

    Research output: Contribution to journalComment/debateResearch

  3. Incidence of Inguinal Hernia after Radical Prostatectomy: A Systematic Review and Meta-Analysis

    Research output: Contribution to journalReviewResearchpeer-review

  4. Editorial Comment

    Research output: Contribution to journalComment/debateResearchpeer-review

  1. Psychiatric disorders in individuals with neurofibromatosis 1 in Denmark: A nationwide register-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Risk of depression after diagnostic prostate cancer workup - A nationwide, registry-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Is the health literacy of informal caregivers associated with the psychological outcomes of breast cancer survivors?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Nationwide Survival Benefit after Implementation of First-Line Immunotherapy for Patients with Advanced NSCLC-Real World Efficacy

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Antidepressant prescriptions and associated factors in men with prostate cancer and their female partners

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

PURPOSE: Evidence on the long-term impact of testicular cancer (TC) treatment on sexual function is not clear. The aim was to estimate the effect of TC treatment on the risk of sexual dysfunction in long-term testicular cancer survivors.

MATERIALS AND METHODS: We conducted a cross-sectional study of 2260 long-term TC survivors (median follow-up 17 years (IQR 12-24 years)) treated with orchiectomy alone (surveillance) (n=1098), bleomycin, etoposide, cisplatin (BEP) (BEP alone or BEP with post chemotherapy retroperitoneal surgery (n=788), abdominal radiotherapy (RT) (n=300), and more than one line of treatment (MTOL) (n=74). Sexual function was evaluated by the International Index of Erectile Function questionnaire (IIEF-15). Results were compared between treatment groups using logistic regression analysis with the results on each of the 5 dimensions of IIEF-15 as outcome, and treatment as exposure using surveillance as reference.

RESULTS: The risk of erectile dysfunction was increased in all treatment groups when compared to surveillance: (BEP alone: Odds ratio (OR) = 1.5 (95% confidence interval (CI): 1.0-2.1), (p<0.05), BEP with post chemotherapy surgery, OR = 2.1 (95% CI: 1.4-3.4), (p<0.005), RT: OR = 1.7 (95% CI: 1.1-2.5), (p<0.05) and MTOL: OR = 3.2 (95% CI: 1.6-6.3), (p<0.005). Orgasmic dysfunction was associated with RT, BEP with post chemotherapy surgery and MTOL.

CONCLUSIONS: Treatment with BEP, RT and MTOL increases the risk of erectile dysfunction in long-term TC-survivors compared to surveillance. Patients should be informed about this as part of the information on treatment related late effects.

Original languageEnglish
JournalThe Journal of urology
Volume200
Issue number4
Pages (from-to)794-800
ISSN0022-5347
DOIs
Publication statusPublished - 2018

ID: 54658554