Abstract
BACKGROUND
Though an appreciation of the influence of sex on the cardiorespiratory outcomes to graded exercise testing is established in literature, less is known about whether these sexual dimorphisms also translate to glycaemic responses in adults with type 1 diabetes (T1D) and if so, whether this needs consideration for clinical management around test performance.
AIM
The aim of this retrospective, pooled analysis was to explore the influence of sex on glycaemic and cardiopulmonary responses to graded exercise testing to exhaustion in adults with T1D using insulin pump therapy.
METHODS
Twenty-three adults with T1D treated with insulin pump therapy undertook an incremental cardiopulmonary exercise test (CPET) to volitional exhaustion on a cycle ergometer.
Cardiopulmonary variables were obtained continuously whilst venous-derived plasma glucose concentrations were collected every 3 minutes during exercise as well as at peak and recovery phases. The anaerobic threshold (AT) was determined as the workload corresponding to the fixed rise in lactate of 1 mmol. L-1 from baseline equating to ~60% peak power. Participants were spilt into
groups based on sex (Table 1). Between group differences were compared via general linear modelling techniques and independent t-tests with p values of ≤0.05 accepted for statistical significance.
RESULTS
Plasma glucose remained comparable to rested concentrations throughout exercise regardless of sex (F (1,21)=2.229, p=0.150) with a minimally equivalent change during the entire testing period (Males: Δ+0.3±1.5 vs. Females: Δ+0.2±0.8 mmol.L-1, p=0.801). Relative to males, females had lower VO2, O2 pulse, (Table1a) and power output (Table 1b) at both submaximal and peak workloads as well as an earlier time to reach the AT and exhaustion.
Females had a lesser reliance on carbohydrates as the dominant fuel during submaximal workloads (Table 1b).
CONCLUSION
These data demonstrate equivalency in plasma glucose responses to incremental exercise testing in males and females with T1D. However, potential sexual dimorphisms in cardiopulmonary responses to CPET may need consideration for optimal exercise prescription and interpretation.
Though an appreciation of the influence of sex on the cardiorespiratory outcomes to graded exercise testing is established in literature, less is known about whether these sexual dimorphisms also translate to glycaemic responses in adults with type 1 diabetes (T1D) and if so, whether this needs consideration for clinical management around test performance.
AIM
The aim of this retrospective, pooled analysis was to explore the influence of sex on glycaemic and cardiopulmonary responses to graded exercise testing to exhaustion in adults with T1D using insulin pump therapy.
METHODS
Twenty-three adults with T1D treated with insulin pump therapy undertook an incremental cardiopulmonary exercise test (CPET) to volitional exhaustion on a cycle ergometer.
Cardiopulmonary variables were obtained continuously whilst venous-derived plasma glucose concentrations were collected every 3 minutes during exercise as well as at peak and recovery phases. The anaerobic threshold (AT) was determined as the workload corresponding to the fixed rise in lactate of 1 mmol. L-1 from baseline equating to ~60% peak power. Participants were spilt into
groups based on sex (Table 1). Between group differences were compared via general linear modelling techniques and independent t-tests with p values of ≤0.05 accepted for statistical significance.
RESULTS
Plasma glucose remained comparable to rested concentrations throughout exercise regardless of sex (F (1,21)=2.229, p=0.150) with a minimally equivalent change during the entire testing period (Males: Δ+0.3±1.5 vs. Females: Δ+0.2±0.8 mmol.L-1, p=0.801). Relative to males, females had lower VO2, O2 pulse, (Table1a) and power output (Table 1b) at both submaximal and peak workloads as well as an earlier time to reach the AT and exhaustion.
Females had a lesser reliance on carbohydrates as the dominant fuel during submaximal workloads (Table 1b).
CONCLUSION
These data demonstrate equivalency in plasma glucose responses to incremental exercise testing in males and females with T1D. However, potential sexual dimorphisms in cardiopulmonary responses to CPET may need consideration for optimal exercise prescription and interpretation.
| Original language | English |
|---|---|
| Publication date | 2022 |
| Publication status | Published - 2022 |
| Event | International Conference on Advanced Technologies and Treatments for Diabetes - Barcelona Duration: 27 Apr 2022 → 30 Apr 2022 |
Conference
| Conference | International Conference on Advanced Technologies and Treatments for Diabetes |
|---|---|
| City | Barcelona |
| Period | 27/04/2022 → 30/04/2022 |