Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Reply: Accelerometers: A Useful Technology in HF Research?

    Research output: Contribution to journalLetterResearchpeer-review

  2. Effects of Dapagliflozin in Patients With Kidney Disease, With and Without Heart Failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Hemodynamic Determinants of Activity Measured by Accelerometer in Patients With Stable Heart Failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Prognostic Value of Peak Oxygen Uptake in Patients Supported With Left Ventricular Assist Devices (PRO-VAD)

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Mineralocorticoid receptor antagonist improves cardiac structure in Type 2 Diabetes: Data from the MIRAD Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Alcohol Intake and Total Mortality in 142,960 Individuals from the MORGAM Project: a population-based study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Tre ønsker for 2022: Mere og bedre fokus på populationer, samarbejder og brug af data.

    Research output: Contribution to journalContribution to newspaper - Feature articleCommunication

  3. Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The power of genetic diversity in genome-wide association studies of lipids

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The age-specific incidence of type 2 diabetes in Danish elderly adults – the role of size at birth

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  • BiomarCaRE Consortium
View graph of relations

OBJECTIVES: This study investigates differences between women and men in heart failure (HF) risk and mortality.

BACKGROUND: Sex differences in HF epidemiology are insufficiently understood.

METHODS: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro-B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men.

RESULTS: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95% confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95% CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95% CI: 0.93 to 1.03) in women versus HR of 1.09 (95% CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95% CI: 1.00 to 1.20) in women versus HR of 1.32 (95% CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95% CI: 1.37 to 1.74) in women versus HR of 1.89 (95% CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0% in women and 62.9% in men.

CONCLUSIONS: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women.

Original languageEnglish
JournalJACC. Heart failure
Volume7
Issue number3
Pages (from-to)204-213
Number of pages10
ISSN2213-1779
DOIs
Publication statusPublished - Mar 2019

ID: 56741035