Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles

Christa Meisinger; Till Ittermann; Daniel Tiller; Carsten Agger; Matthias Nauck; Sabine Schipf; Henri Wallaschofski; Torben Jørgensen; Allan Linneberg; Joachim Thiery; Alexander Kluttig; Karin H Greiser; Karl Werdan; Katrin Burkhardt; Henry Völzke

doi:10.1089/thy.2013.0259

Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles

Christa Meisinger, Till Ittermann, Daniel Tiller, Carsten Agger, Matthias Nauck, Sabine Schipf, Henri Wallaschofski, Torben Jørgensen, Allan Linneberg, Joachim Thiery, Alexander Kluttig, Karin H Greiser, Karl Werdan, Katrin Burkhardt, Henry Völzke

23 Citations (Scopus)

Abstract

Background: Population-based studies investigating the sex-specific association between thyrotropin (TSH) levels and serum lipid concentrations are scarce. We examined the association between TSH and total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglycerides in men and women from the general population. Furthermore, the association with TSH outside and within the reference range and lipid levels was studied. Methods: Individual data of 13,571 men and women without lipid medication of four population-based studies conducted in Western European adults were pooled for cross-sectional analyses. The association between TSH levels and lipid concentrations were analyzed by calculating sex-specific multivariable median regression models. Results: In the pooled population, serum TSH levels were significantly positively associated with triglyceride values in men and with total cholesterol, LDL cholesterol, and triglyceride values in women. In the pooled male population, low serum TSH levels (

Original language	English
Journal	Thyroid : official journal of the American Thyroid Association
Volume	24
Issue number	3
Pages (from-to)	424-432
Number of pages	8
ISSN	1050-7256
DOIs	https://doi.org/10.1089/thy.2013.0259
Publication status	Published - Mar 2014

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Meisinger, C., Ittermann, T., Tiller, D., Agger, C., Nauck, M., Schipf, S., Wallaschofski, H., Jørgensen, T., Linneberg, A., Thiery, J., Kluttig, A., Greiser, K. H., Werdan, K., Burkhardt, K., & Völzke, H. (2014). Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles. Thyroid : official journal of the American Thyroid Association, 24(3), 424-432. https://doi.org/10.1089/thy.2013.0259

Meisinger, C, Ittermann, T, Tiller, D, Agger, C, Nauck, M, Schipf, S, Wallaschofski, H, Jørgensen, T , Linneberg, A, Thiery, J, Kluttig, A, Greiser, KH, Werdan, K, Burkhardt, K & Völzke, H 2014, 'Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles', Thyroid : official journal of the American Thyroid Association, vol. 24, no. 3, pp. 424-432. https://doi.org/10.1089/thy.2013.0259

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title = "Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles",

abstract = "Background: Population-based studies investigating the sex-specific association between thyrotropin (TSH) levels and serum lipid concentrations are scarce. We examined the association between TSH and total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglycerides in men and women from the general population. Furthermore, the association with TSH outside and within the reference range and lipid levels was studied. Methods: Individual data of 13,571 men and women without lipid medication of four population-based studies conducted in Western European adults were pooled for cross-sectional analyses. The association between TSH levels and lipid concentrations were analyzed by calculating sex-specific multivariable median regression models. Results: In the pooled population, serum TSH levels were significantly positively associated with triglyceride values in men and with total cholesterol, LDL cholesterol, and triglyceride values in women. In the pooled male population, low serum TSH levels (",

author = "Christa Meisinger and Till Ittermann and Daniel Tiller and Carsten Agger and Matthias Nauck and Sabine Schipf and Henri Wallaschofski and Torben J{\o}rgensen and Allan Linneberg and Joachim Thiery and Alexander Kluttig and Greiser, \{Karin H\} and Karl Werdan and Katrin Burkhardt and Henry V{\"o}lzke",

year = "2014",

month = mar,

doi = "10.1089/thy.2013.0259",

language = "English",

volume = "24",

pages = "424--432",

journal = "Thyroid : official journal of the American Thyroid Association",

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T1 - Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles

AU - Meisinger, Christa

AU - Ittermann, Till

AU - Tiller, Daniel

AU - Agger, Carsten

AU - Nauck, Matthias

AU - Schipf, Sabine

AU - Wallaschofski, Henri

AU - Jørgensen, Torben

AU - Linneberg, Allan

AU - Thiery, Joachim

AU - Kluttig, Alexander

AU - Greiser, Karin H

AU - Werdan, Karl

AU - Burkhardt, Katrin

AU - Völzke, Henry

PY - 2014/3

Y1 - 2014/3

N2 - Background: Population-based studies investigating the sex-specific association between thyrotropin (TSH) levels and serum lipid concentrations are scarce. We examined the association between TSH and total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglycerides in men and women from the general population. Furthermore, the association with TSH outside and within the reference range and lipid levels was studied. Methods: Individual data of 13,571 men and women without lipid medication of four population-based studies conducted in Western European adults were pooled for cross-sectional analyses. The association between TSH levels and lipid concentrations were analyzed by calculating sex-specific multivariable median regression models. Results: In the pooled population, serum TSH levels were significantly positively associated with triglyceride values in men and with total cholesterol, LDL cholesterol, and triglyceride values in women. In the pooled male population, low serum TSH levels (

AB - Background: Population-based studies investigating the sex-specific association between thyrotropin (TSH) levels and serum lipid concentrations are scarce. We examined the association between TSH and total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglycerides in men and women from the general population. Furthermore, the association with TSH outside and within the reference range and lipid levels was studied. Methods: Individual data of 13,571 men and women without lipid medication of four population-based studies conducted in Western European adults were pooled for cross-sectional analyses. The association between TSH levels and lipid concentrations were analyzed by calculating sex-specific multivariable median regression models. Results: In the pooled population, serum TSH levels were significantly positively associated with triglyceride values in men and with total cholesterol, LDL cholesterol, and triglyceride values in women. In the pooled male population, low serum TSH levels (

UR - https://www.scopus.com/pages/publications/84896757461

U2 - 10.1089/thy.2013.0259

DO - 10.1089/thy.2013.0259

M3 - Journal article

C2 - 24102572

SN - 1050-7256

VL - 24

SP - 424

EP - 432

JO - Thyroid : official journal of the American Thyroid Association

JF - Thyroid : official journal of the American Thyroid Association

IS - 3

ER -

Sex-Specific Associations Between Thyrotropin and Serum Lipid Profiles

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