Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Costs of subcutaneous and intravenous administration of trastuzumab for patients with HER2-positive breast cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Localization, distribution, and connectivity of neuropeptide Y in the human and porcine retinas - a comparative study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Melanopsin expressing human retinal ganglion cells: Subtypes, distribution and intraretinal connectivity

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. The Preoptic Area and the RFamide-Related Peptide Neuronal System Gate Seasonal Changes in Chemosensory Processing

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Jo B Henningsen
  • Vincent-Joseph Poirel
  • Jens D Mikkelsen
  • Kazuyoshi Tsutsui
  • Valérie Simonneaux
  • François Gauer
View graph of relations

RF-(Arg-Phe) related peptides (RFRP-1 and -3) are considered to play a role in the seasonal regulation of reproduction; however, the effect of the peptides depends on species and gender. This study aimed at comparing the RFRP system in male and female Syrian hamsters over long and short photoperiods to investigate the neuroanatomical basis of these differential effects. The neuroanatomical distribution of RFRP neurons and fibers, revealed using an antiserum recognizing RFRP-1 and -3, as well as GPR147 mRNA, are similar in male and female Syrian hamsters. RFRP neurons are mainly found in the medial hypothalamus, whereas RFRP projections and GPR147 mRNA are observed in the preoptic area, anteroventral-periventricular nucleus, suprachiasmatic nucleus, paraventricular nucleus, bed nucleus of the stria terminalis, ventromedial hypothalamus, habenular nucleus, and arcuate nucleus. The number of RFRP neurons is higher in females than in males, and in both sexes, the number of RFRP neurons is reduced in short photoperiods. GPR147 mRNA levels are higher in females than in males and are downregulated in short photoperiods, particularly in females. Interestingly, the number of RFRP-positive fibers in the anteroventral-periventricular nucleus is higher only in females adjusted to a short photoperiod. Our results suggest that the RFRP system, which is strongly regulated by photoperiod in both male and female Syrian hamsters, is particularly important in females, with a distinct role in the anteroventral-periventricular nucleus, possibly in the regulation of the preovulatory luteinizing hormone surge via kisspeptin neurons. J. Comp. Neurol. 524:1825-1838, 2016. © 2015 Wiley Periodicals, Inc.

Original languageEnglish
JournalThe Journal of comparative neurology
Volume524
Issue number9
Pages (from-to)1825-38
Number of pages14
ISSN0021-9967
DOIs
Publication statusPublished - 15 Jun 2016

ID: 46492827