Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Sex Differences in the Achievement of Remission and Low Disease Activity in Rheumatoid Arthritis

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Maynard, C, Mikuls, TR, Cannon, GW, England, BR, Conaghan, PG, Østergaard, M, Baker, DG, Kerr, G, George, MD, Barton, JL & Baker, JF 2020, 'Sex Differences in the Achievement of Remission and Low Disease Activity in Rheumatoid Arthritis' Arthritis Care & Research, vol. 72, no. 3, pp. 326-333. https://doi.org/10.1002/acr.23873

APA

Maynard, C., Mikuls, T. R., Cannon, G. W., England, B. R., Conaghan, P. G., Østergaard, M., ... Baker, J. F. (2020). Sex Differences in the Achievement of Remission and Low Disease Activity in Rheumatoid Arthritis. Arthritis Care & Research, 72(3), 326-333. https://doi.org/10.1002/acr.23873

CBE

Maynard C, Mikuls TR, Cannon GW, England BR, Conaghan PG, Østergaard M, Baker DG, Kerr G, George MD, Barton JL, Baker JF. 2020. Sex Differences in the Achievement of Remission and Low Disease Activity in Rheumatoid Arthritis. Arthritis Care & Research. 72(3):326-333. https://doi.org/10.1002/acr.23873

MLA

Vancouver

Author

Maynard, Carson ; Mikuls, Ted R ; Cannon, Grant W ; England, Bryant R ; Conaghan, Philip G ; Østergaard, Mikkel ; Baker, Daniel G ; Kerr, Gail ; George, Michael D ; Barton, Jennifer L ; Baker, Joshua F. / Sex Differences in the Achievement of Remission and Low Disease Activity in Rheumatoid Arthritis. In: Arthritis Care & Research. 2020 ; Vol. 72, No. 3. pp. 326-333.

Bibtex

@article{23a62cad67d14ed18eb0a3a1acfd5978,
title = "Sex Differences in the Achievement of Remission and Low Disease Activity in Rheumatoid Arthritis",
abstract = "OBJECTIVE: In rheumatoid arthritis, whether women are less likely to achieve low disease activity is unclear. We evaluated sex differences in remission and low disease activity, comparing different clinical and imaging measures.METHODS: We used data from the Veterans Affairs Rheumatoid Arthritis (VARA) registry and from 2 clinical trials. Remission and low disease activity were defined using composite scores, individual items (tender joints, swollen joints, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] level, and evaluator/patient global assessment), and magnetic resonance imaging (MRI). In the VARA registry, we assessed the likelihood of point remission at any time during follow-up using logistic regression, and time to sustained remission (2 consecutive visits) using Cox proportional hazards models. In the clinical trials, logistic regression models evaluated the likelihood of low clinical and MRI activity at 52 weeks.RESULTS: Among 2,463 patients in VARA, women (10.2{\%}) were less likely to be in Disease Activity Score in 28 joints (DAS28)-ESR remission in follow-up (odds ratio [OR] 0.71 [95{\%} confidence interval (95{\%} CI) 0.55-0.91]; P < 0.01) and had a longer time to sustained DAS28-ESR remission. This difference was not observed for DAS28-CRP, Clinical Disease Activity Index, or Routine Assessment of Patient Index Data 3. Women were more likely to achieve favorable individual components except for an ESR <30 mm/hour (OR 0.72 [95{\%} CI 0.57-0.90]; P < 0.01). Among 353 trial participants (83.7{\%} women), women had reduced rates of DAS28-ESR remission (OR 0.39 [95{\%} CI 0.21-0.72]; P = 0.003) but similar rates of low MRI synovitis and osteitis.CONCLUSION: The comparison of remission rates between men and women varies based on the disease activity measure, with sex-specific differences in ESR resulting in reliably lower rates of remission among women. There were no differences in MRI measures.",
author = "Carson Maynard and Mikuls, {Ted R} and Cannon, {Grant W} and England, {Bryant R} and Conaghan, {Philip G} and Mikkel {\O}stergaard and Baker, {Daniel G} and Gail Kerr and George, {Michael D} and Barton, {Jennifer L} and Baker, {Joshua F}",
note = "{\circledC} 2019 American College of Rheumatology. This article has been contributed to by US Government employees and their work is in the public domain in the USA.",
year = "2020",
month = "3",
doi = "10.1002/acr.23873",
language = "English",
volume = "72",
pages = "326--333",
journal = "Arthritis Care & Research",
issn = "2151-464X",
publisher = "JohnWiley & Sons, Inc",
number = "3",

}

RIS

TY - JOUR

T1 - Sex Differences in the Achievement of Remission and Low Disease Activity in Rheumatoid Arthritis

AU - Maynard, Carson

AU - Mikuls, Ted R

AU - Cannon, Grant W

AU - England, Bryant R

AU - Conaghan, Philip G

AU - Østergaard, Mikkel

AU - Baker, Daniel G

AU - Kerr, Gail

AU - George, Michael D

AU - Barton, Jennifer L

AU - Baker, Joshua F

N1 - © 2019 American College of Rheumatology. This article has been contributed to by US Government employees and their work is in the public domain in the USA.

PY - 2020/3

Y1 - 2020/3

N2 - OBJECTIVE: In rheumatoid arthritis, whether women are less likely to achieve low disease activity is unclear. We evaluated sex differences in remission and low disease activity, comparing different clinical and imaging measures.METHODS: We used data from the Veterans Affairs Rheumatoid Arthritis (VARA) registry and from 2 clinical trials. Remission and low disease activity were defined using composite scores, individual items (tender joints, swollen joints, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] level, and evaluator/patient global assessment), and magnetic resonance imaging (MRI). In the VARA registry, we assessed the likelihood of point remission at any time during follow-up using logistic regression, and time to sustained remission (2 consecutive visits) using Cox proportional hazards models. In the clinical trials, logistic regression models evaluated the likelihood of low clinical and MRI activity at 52 weeks.RESULTS: Among 2,463 patients in VARA, women (10.2%) were less likely to be in Disease Activity Score in 28 joints (DAS28)-ESR remission in follow-up (odds ratio [OR] 0.71 [95% confidence interval (95% CI) 0.55-0.91]; P < 0.01) and had a longer time to sustained DAS28-ESR remission. This difference was not observed for DAS28-CRP, Clinical Disease Activity Index, or Routine Assessment of Patient Index Data 3. Women were more likely to achieve favorable individual components except for an ESR <30 mm/hour (OR 0.72 [95% CI 0.57-0.90]; P < 0.01). Among 353 trial participants (83.7% women), women had reduced rates of DAS28-ESR remission (OR 0.39 [95% CI 0.21-0.72]; P = 0.003) but similar rates of low MRI synovitis and osteitis.CONCLUSION: The comparison of remission rates between men and women varies based on the disease activity measure, with sex-specific differences in ESR resulting in reliably lower rates of remission among women. There were no differences in MRI measures.

AB - OBJECTIVE: In rheumatoid arthritis, whether women are less likely to achieve low disease activity is unclear. We evaluated sex differences in remission and low disease activity, comparing different clinical and imaging measures.METHODS: We used data from the Veterans Affairs Rheumatoid Arthritis (VARA) registry and from 2 clinical trials. Remission and low disease activity were defined using composite scores, individual items (tender joints, swollen joints, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP] level, and evaluator/patient global assessment), and magnetic resonance imaging (MRI). In the VARA registry, we assessed the likelihood of point remission at any time during follow-up using logistic regression, and time to sustained remission (2 consecutive visits) using Cox proportional hazards models. In the clinical trials, logistic regression models evaluated the likelihood of low clinical and MRI activity at 52 weeks.RESULTS: Among 2,463 patients in VARA, women (10.2%) were less likely to be in Disease Activity Score in 28 joints (DAS28)-ESR remission in follow-up (odds ratio [OR] 0.71 [95% confidence interval (95% CI) 0.55-0.91]; P < 0.01) and had a longer time to sustained DAS28-ESR remission. This difference was not observed for DAS28-CRP, Clinical Disease Activity Index, or Routine Assessment of Patient Index Data 3. Women were more likely to achieve favorable individual components except for an ESR <30 mm/hour (OR 0.72 [95% CI 0.57-0.90]; P < 0.01). Among 353 trial participants (83.7% women), women had reduced rates of DAS28-ESR remission (OR 0.39 [95% CI 0.21-0.72]; P = 0.003) but similar rates of low MRI synovitis and osteitis.CONCLUSION: The comparison of remission rates between men and women varies based on the disease activity measure, with sex-specific differences in ESR resulting in reliably lower rates of remission among women. There were no differences in MRI measures.

U2 - 10.1002/acr.23873

DO - 10.1002/acr.23873

M3 - Journal article

VL - 72

SP - 326

EP - 333

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 2151-464X

IS - 3

ER -

ID: 58909637