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Sex differences in acromegaly at diagnosis: A nationwide cohort study and meta-analysis of the literature

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Dal, Jakob ; Skov, Benedikte G ; Andersen, Marianne ; Feldt-Rasmussen, Ulla ; Feltoft, Claus L ; Karmisholt, Jesper Scott ; Nielsen, Eigil H ; Dekkers, Olaf M ; Jørgensen, Jens Otto L. / Sex differences in acromegaly at diagnosis : A nationwide cohort study and meta-analysis of the literature. In: Clinical Endocrinology. 2020.

Bibtex

@article{61fbde27602a451d9a888e361f0a6732,
title = "Sex differences in acromegaly at diagnosis: A nationwide cohort study and meta-analysis of the literature",
abstract = "OBJECTIVE: Data on sex differences in acromegaly at the time of diagnosis vary considerably between studies.DESIGN: A nationwide cohort study including all incident cases of acromegaly (1978-2010, n = 596) and a meta-analysis on sex differences in active acromegaly (40 studies) were performed.METHOD: Sex-dependent differences in prevalence, age at diagnosis, diagnostic delay, pituitary adenoma size, insulin-like growth factor 1 (IGF-I) and growth hormone (GH) concentrations were estimated.RESULTS: The cohort study identified a balanced gender distribution (49.6% females) and a comparable age (years) at diagnosis (48.2 CI95% 46.5-49.8 (males) vs. 47.2 CI95% 45.5-48.9 (females), p = 0.4). The incidence rate significantly increased during the study period (R2 = 0.42, p < 0.01) and the gender ratio (F/M) changed from female predominance to an even ratio (SR: 1.4 vs. 0.9, p = 0.03). IGF-ISDS was significantly lower in females compared to males, whereas neither nadir GH nor pituitary adenoma size differed between males and females. In the meta-analysis, the weighted percentage female was 53.3% (CI95% 51.5-55.2) with considerable heterogeneity (I2 = 85%) among the studies. The mean age difference at diagnosis between genders was 3.1 years (CI95% 1.9-4.4), and the diagnostic delay was longer in females by 0.9 years (CI95% -0.4 to 2.1). Serum IGF-I levels were significantly lower in female patients, whereas nadir GH, and pituitary adenoma size were comparable.CONCLUSION: There are only a minor sex differences in the epidemiology of acromegaly at the time of diagnosis except that female patients are slightly older and exhibit lower IGF-I concentrations and a longer diagnostic delay.",
author = "Jakob Dal and Skov, {Benedikte G} and Marianne Andersen and Ulla Feldt-Rasmussen and Feltoft, {Claus L} and Karmisholt, {Jesper Scott} and Nielsen, {Eigil H} and Dekkers, {Olaf M} and J{\o}rgensen, {Jens Otto L}",
note = "{\textcopyright} 2020 John Wiley & Sons Ltd.",
year = "2020",
month = dec,
day = "11",
doi = "10.1111/cen.14392",
language = "English",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell Publishing Ltd",

}

RIS

TY - JOUR

T1 - Sex differences in acromegaly at diagnosis

T2 - A nationwide cohort study and meta-analysis of the literature

AU - Dal, Jakob

AU - Skov, Benedikte G

AU - Andersen, Marianne

AU - Feldt-Rasmussen, Ulla

AU - Feltoft, Claus L

AU - Karmisholt, Jesper Scott

AU - Nielsen, Eigil H

AU - Dekkers, Olaf M

AU - Jørgensen, Jens Otto L

N1 - © 2020 John Wiley & Sons Ltd.

PY - 2020/12/11

Y1 - 2020/12/11

N2 - OBJECTIVE: Data on sex differences in acromegaly at the time of diagnosis vary considerably between studies.DESIGN: A nationwide cohort study including all incident cases of acromegaly (1978-2010, n = 596) and a meta-analysis on sex differences in active acromegaly (40 studies) were performed.METHOD: Sex-dependent differences in prevalence, age at diagnosis, diagnostic delay, pituitary adenoma size, insulin-like growth factor 1 (IGF-I) and growth hormone (GH) concentrations were estimated.RESULTS: The cohort study identified a balanced gender distribution (49.6% females) and a comparable age (years) at diagnosis (48.2 CI95% 46.5-49.8 (males) vs. 47.2 CI95% 45.5-48.9 (females), p = 0.4). The incidence rate significantly increased during the study period (R2 = 0.42, p < 0.01) and the gender ratio (F/M) changed from female predominance to an even ratio (SR: 1.4 vs. 0.9, p = 0.03). IGF-ISDS was significantly lower in females compared to males, whereas neither nadir GH nor pituitary adenoma size differed between males and females. In the meta-analysis, the weighted percentage female was 53.3% (CI95% 51.5-55.2) with considerable heterogeneity (I2 = 85%) among the studies. The mean age difference at diagnosis between genders was 3.1 years (CI95% 1.9-4.4), and the diagnostic delay was longer in females by 0.9 years (CI95% -0.4 to 2.1). Serum IGF-I levels were significantly lower in female patients, whereas nadir GH, and pituitary adenoma size were comparable.CONCLUSION: There are only a minor sex differences in the epidemiology of acromegaly at the time of diagnosis except that female patients are slightly older and exhibit lower IGF-I concentrations and a longer diagnostic delay.

AB - OBJECTIVE: Data on sex differences in acromegaly at the time of diagnosis vary considerably between studies.DESIGN: A nationwide cohort study including all incident cases of acromegaly (1978-2010, n = 596) and a meta-analysis on sex differences in active acromegaly (40 studies) were performed.METHOD: Sex-dependent differences in prevalence, age at diagnosis, diagnostic delay, pituitary adenoma size, insulin-like growth factor 1 (IGF-I) and growth hormone (GH) concentrations were estimated.RESULTS: The cohort study identified a balanced gender distribution (49.6% females) and a comparable age (years) at diagnosis (48.2 CI95% 46.5-49.8 (males) vs. 47.2 CI95% 45.5-48.9 (females), p = 0.4). The incidence rate significantly increased during the study period (R2 = 0.42, p < 0.01) and the gender ratio (F/M) changed from female predominance to an even ratio (SR: 1.4 vs. 0.9, p = 0.03). IGF-ISDS was significantly lower in females compared to males, whereas neither nadir GH nor pituitary adenoma size differed between males and females. In the meta-analysis, the weighted percentage female was 53.3% (CI95% 51.5-55.2) with considerable heterogeneity (I2 = 85%) among the studies. The mean age difference at diagnosis between genders was 3.1 years (CI95% 1.9-4.4), and the diagnostic delay was longer in females by 0.9 years (CI95% -0.4 to 2.1). Serum IGF-I levels were significantly lower in female patients, whereas nadir GH, and pituitary adenoma size were comparable.CONCLUSION: There are only a minor sex differences in the epidemiology of acromegaly at the time of diagnosis except that female patients are slightly older and exhibit lower IGF-I concentrations and a longer diagnostic delay.

U2 - 10.1111/cen.14392

DO - 10.1111/cen.14392

M3 - Journal article

C2 - 33306249

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

ER -

ID: 61807664