Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione, testosterone and their ratios in children, adolescents and young adults

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Evaluation of algorithm development approaches: Development of biomarker panels for early detection of colorectal lesions

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Methodological development and biological observations of cell free DNA with a simple direct fluorescent assay in colorectal cancer

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Clinical proteomics: Insights from IGF-I

    Research output: Contribution to journalReviewResearchpeer-review

  4. Validation of image cytometry for sperm concentration measurement: Comparison with manual counting of 4010 human semen samples

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Clinical usefulness of bone turnover marker concentrations in osteoporosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. High maternal age at first and subsequent child births in Denmark in the mid-1800s-Letter to the editor

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Development and Interlaboratory Validation of Two Fast UPLC-MS-MS Methods Determining Urinary Bisphenols, Parabens and Phthalates

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The influence of sex, age, pubertal development and oral contraceptives on dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), 17α-hydroxyprogesterone (17-OHP), Δ4-androstenedione (Adione), testosterone (T), calculated free testosterone (fT), free androgen index (FAI) and selected ratios in 1798 serum samples from healthy children, adolescents and young adults was evaluated. Samples were analyzed by Turboflow-LC-MS/MS. Sex hormone-binding globulin was analyzed by immunoassay. All steroid metabolite concentrations were positively associated with age and pubertal development in both sexes and generally higher in males than in females except for Adione. The pubertal rise in T in males was more pronounced compared to females, reflecting contribution from the testes. Ratios between steroid metabolites varied and depended on sex and age. All ratios were lower during infancy compared to later in life. Use of oral contraceptives significantly lowered serum concentrations of all steroid metabolites, fT, FAI, the 17-OHP/Adione, the Adione/T and the DHEA/Adione ratios, but not the DHEA/DHEAS ratio. We provide reference ranges for DHEA, DHEAS, 17-OHP, Adione, T, fT, FAI and selected ratios in relation to sex, age and pubertal development. Use of oral contraceptives strongly influences adrenal steroidogenesis and should be considered when diagnosing and monitoring treatment of patients with disorders of sex development.

Original languageEnglish
JournalClinica chimica acta; international journal of clinical chemistry
Volume437
Pages (from-to)6-13
Number of pages8
ISSN0009-8981
DOIs
Publication statusPublished - 1 Nov 2014

ID: 44859617