Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Severity of self-reported depressive symptoms in a healthy sample is modulated by trait Harm Avoidance, not by 5-HTTLPR polymorphism

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Sex differences in trauma exposure and symptomatology in trauma-affected refugees

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Associations between facial affect recognition and neurocognition in subjects at ultra-high risk for psychosis: A case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: The length of the serotonin transporter polymorphic region (5-HTTLPR) has been suggested to be associated with risk for developing depression, though with inconsistent evidence. Likewise, the personality trait Harm Avoidance (HA) has been linked to vulnerability for developing depression. However, no study has investigated whether there is an interaction effect between 5-HTTLPR and trait HA on depressive symptoms in healthy individuals.

METHODS: A total of 319 healthy individuals were included in this cross-sectional study. All participants were genotyped for the 5-HTTLPR polymorphism and completed self-reported measures of personality trait HA with the Temperament and Character Inventory (TCI), and of depression with the Major Depression Inventory (MDI). Linear regression analyses were used to test interaction effects between 5-HTTLPR and HA on MDI. Post hoc analyses were further performed to investigate main effects of HA and possible interaction effects between 5-HTTLPR and HA sub-scales on MDI.

RESULTS: No significant interaction effect between 5-HTTLPR and HA on MDI was found. A significant main effect of trait HA on MDI was found, indicating that personality trait HA is a viable vulnerability factor for even sub-clinical depressive symptoms.

CONCLUSION: This study finds a strong significant relationship between HA and MDI. Moreover, the present study supports the line of research indicating that candidate gene-by-interactions does not increase vulnerability for developing depression even at a sub-clinical level.

Original languageEnglish
JournalPsychiatry Research
Volume291
Pages (from-to)113029
ISSN0165-1781
DOIs
Publication statusPublished - Sep 2020

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Avoidance Learning/physiology, Character, Cross-Sectional Studies, Depressive Disorder/diagnosis, Female, Harm Reduction/physiology, Humans, Male, Middle Aged, Polymorphism, Genetic/genetics, Self Report, Serotonin Plasma Membrane Transport Proteins/genetics, Severity of Illness Index, Temperament/physiology, Young Adult

ID: 61732600