Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Severity of chronic obstructive pulmonary disease and presenting rhythm in patients with out-of-hospital cardiac arrest

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Age-specific trends in incidence and survival of out-of-hospital cardiac arrest from presumed cardiac cause in Denmark 2002-2014

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Occurrence of shockable rhythm in out-of-hospital cardiac arrest over time: a report from the COSTA group

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prevalence and incidence of various Cancer subtypes in patients with heart failure vs matched controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Antihypertensive Drugs and Risk of Depression: A Nationwide Population-Based Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Long-term impact of baseline anaemia on clinical outcomes following percutaneous coronary intervention in stable angina

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Self-reported health status and the associated risk of mortality in heart failure: The DANISH trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Differences in mortality in patients undergoing surgery for infective endocarditis according to age and valvular surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is associated with a non-shockable rhythm as presenting rhythm in out-of-hospital cardiac arrest (OHCA). Whether the severity of the underlying disease is related to presenting rhythm is unknown. We hypothesize that increased severity of COPD in OHCA patients is associated with an increased prevalence of non-shockable rhythm.

METHODS: This study included OHCA patients ≥40 years from the Danish Cardiac Arrest Registry (2001-2014). Population-based registries were used to identify chronic diseases and drug prescriptions. COPD was defined as a COPD diagnosis or pharmacological therapy for COPD. The severity of COPD was based on either 1) pharmacological therapy (mild/moderate/severe), 2) admission for exacerbation, 3) prescription for corticosteroids, or 4) forced expiratory volume in 1 second (FEV1). For each of these, a multivariable logistic regression model was used to estimate odds ratios (ORs) for a non-shockable rhythm.

RESULTS: Of 33,228 patients with OHCA 7,789 (23.4%) had COPD. Of these 6,702 (86.0%) had a non-shockable rhythm. Compared to patients without COPD, mild COPD was associated with a non-shockable rhythm (OR = 1.46, 95%CI 1.29-1.65). This association was more pronounced for moderate (OR = 1.78, 95%CI 1.45-2.19) and severe COPD (OR = 2.01 95%CI 1.82-2.20). Recent admission for exacerbation (OR = 2.12, OR 95%CI 1.81-2.49) or prescription for corticosteroids (OR = 1.82, 95%CI 1.55-2.14) was also associated with a non-shockable rhythm. FEV1 ≤50% was associated with a non-shockable rhythm compared to FEV1 > 50% (OR = 1.74, 95%CI 1.07-2.82, n = 1122).

CONCLUSION: Incremental severity of COPD is associated with increasing prevalence of a non-shockable rhythm as presenting rhythm in OHCA patients.

Original languageEnglish
JournalResuscitation
Volume126
Pages (from-to)111-117
Number of pages7
ISSN0300-9572
DOIs
Publication statusPublished - May 2018

    Research areas

  • Journal Article

ID: 53432078