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Severe loss of right ventricular longitudinal contraction occurs after cardiopulmonary bypass in patients with preserved right ventricular output

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Assessment of right ventricular (RV) function is crucial since RV failure with a reduced cardiac output (CO) is associated with compromised outcome in cardiac surgery. Echocardiographic evaluation of RV function is commonly used, but a reduction in tricuspid annular plane systolic excursion (TAPSE) and tricuspid annulus tissue Doppler imaging (S') have been observed independently of clinical signs of RV failure. This has led to uncertainty of these variables' validity in cardiac surgery. To describe transesophageal echocardiographic (TEE) measures of RV function during coronary artery bypass graft surgery with detailed haemodynamic assessment using pulmonary artery catheter (PAC) measurements to describe "natural" changes in the absence of RV failure. We prospectively studied 30 patients with concomitant PAC and TEE measurements at four time-points, namely after: anaesthesia induction, sternotomy, cardiopulmonary bypass (CPB) and upon arrival in the intensive care unit. TAPSE and S' were significantly reduced by 43% (p < 0.0001) and 22% (p = 0.006), respectively after CPB without any change in stroke volume (SV). RV ejection fraction (RVEF), RV fractional area change (RVFAC) and global longitudinal strain (RV-GLS) remained unchanged. SV measured with 3D echocardiography correlated with PAC measured SV (r = 0.66[95% CI 0.50; 0.78], p < 0.0001), but 3D showed a minor, but statistically significant underestimation of SV (8.5 ml (95% CI 2.7 ml; 14 ml, p = 0.004). TAPSE and S' were both reduced after CPB despite maintained CO. RVFAC, RVEF and RV-GLS remained stable, however, these measures were unable to detect minor changes in SV. 3D-echocardiographyshowed a strong correlation with SV measured by thermodilution, but with a consistent underestimation of approximately 10%.

Original languageEnglish
JournalThe international journal of cardiovascular imaging
Issue number9
Pages (from-to)1661-1670
Number of pages10
Publication statusPublished - 2019

    Research areas

  • Coronary artery bypass graft surgery, Global longitudinal strain, Right ventricle, Three-dimensional echocardiography, Tricuspid annular plane systolic excursion, Predictive Value of Tests, Echocardiography, Transesophageal, Prospective Studies, Humans, Middle Aged, Catheterization, Swan-Ganz, Male, Ventricular Dysfunction, Right/diagnostic imaging, Time Factors, Female, Coronary Artery Bypass/adverse effects, Severity of Illness Index, Reproducibility of Results, Cardiopulmonary Bypass/adverse effects, Echocardiography, Three-Dimensional, Treatment Outcome, Coronary Artery Disease/diagnostic imaging, Stroke Volume, Thermodilution, Aged, Ventricular Function, Right

ID: 57664287