Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Serum proatrial natriuretic peptide concentrations during oral glucose-induced acute hyperinsulinemia in lean and obese men

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Procholecystokinin expression and processing in cardiac myocytes

    Research output: Contribution to journalReviewResearchpeer-review

  2. Cardiac procholecystokinin expression during haemodynamic changes in the mammalian heart

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Hypovolemia and reduced hemoglobin mass in patients with heart failure and preserved ejection fraction

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Transcriptome analysis in patients with temporal lobe epilepsy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cardiovascular Manifestations of Systemic Sclerosis: A Danish Nationwide Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Atrial natriuretic peptide (ANP) is primarily seen as a hormone involved in salt and water homeostasis and blood pressure regulation. Evidence supports a link between metabolism and ANP. Circulating ANP concentrations are low in obese individuals with insulin resistance and hyperinsulinemia. The dynamic relationship between insulin and ANP has been sparsely studied. We therefore measured circulating concentrations of midregional proatrial natriuretic peptide (MR-proANP), a stable marker of ANP secretion, and insulin in lean and obese men during an oral glucose challenge. One hundred and three obese men (body mass index (BMI) ≥30.0 kg/m2) were compared with 27 lean men (BMI = 20.0-24.9 kg/m2). During a 75 g oral glucose challenge, circulating concentrations of MR-proANP and insulin were measured at baseline and every half hour for 2 h. Fasting MR-proANP concentrations were lower in the obese men as compared with the lean men (median (interquartile range): 51.2 (38.7-64.7) pmol/L vs. 69.3 (54.3-82.9) pmol/L, P = 0.002). During the oral glucose challenge, serum MR-proANP concentrations fell steadily in the obese men (P < 0.0001), whereas there was no significant fall in the lean men (P = 0.14). However, the time-course curves of MR-proANP did not display a clear reciprocal relation to the time-course curves of insulin. Adjusted for age, the area under curve (AUC) for MR-proANP was inversely correlated with AUC for insulin (r = -0.38, P < 0.0001). In conclusion, during an oral glucose challenge, serum MR-proANP concentrations drop significantly in obese individuals, but the time-course curves of MR-proANP do not display a reciprocal relationship to the time-course curves of insulin.

Original languageEnglish
JournalPeptides
Volume111
Pages (from-to)98-102
Number of pages5
ISSN0196-9781
DOIs
Publication statusPublished - Jan 2019

    Research areas

  • Atrial natriuretic peptide, Glucose challenge, Insulin, Insulin resistance, Proatrial natriuretic peptide

ID: 53548059