Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Serum metabolites associate with CT findings following TBI

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. SERUM METABOLITES ASSOCIATE WITH HEAD COMPUTED TOMOGRAPHY FINDINGS FOLLOWING TRAUMATIC BRAIN INJURY

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  2. Feasibility of Telemetric Intracranial Pressure Monitoring in the Neuro Intensive Care Unit

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Facilitators and Barriers to International Collaboration in Spinal Cord Injury: Results from a Survey of Clinicians and Researchers

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Polyols and Branched Chained Amino Acids Are Associated with Present and Future Renal Impairment in Type 1 Diabetes

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  2. Targeted Clinical Metabolite Profiling Platform for the Stratification of Diabetic Patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Circulating metabolites are associated with present and future renal impairment in type 1 Diabetes

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  4. Renal function dominates the landscape of the metabolome in type 1 diabetes

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  • Alex Mountfort Dickens
  • Jussi P Posti
  • Riikka Sk Takala
  • Henna Maria Ala-Seppälä
  • Ismo Mattila
  • Jonathan Coles Coles
  • Janek Frantzén
  • Peter John Hutchinson
  • Ari J Katila
  • Anna Kyllönen
  • Henna-Riikka Maanpää
  • Virginia Newcombe
  • Joanne Outtrim
  • Jussi Tallus
  • Keri Carpenter
  • David Menon
  • Tuulia Hyotylainen
  • Olli Tenovuo
  • Matej Oresic
View graph of relations

There is a need to rapidly detect patients with traumatic brain injury (TBI) who require head computed tomography (CT). Given the energy crisis in the brain following TBI, we hypothesized that serum metabolomics would be a useful tool for developing a set of biomarkers to determine the need for CT and to distinguish between different types of injuries observed. Logistic regression models using metabolite data from the discovery cohort (n=144, Turku, Finland) were used to distinguish between patients with traumatic intracranial findings and negative findings on head CT. The resultant models were then tested in the validation cohort (n=66, Cambridge, UK). The levels of glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 were also quantified in the serum from the same patients. Despite there being significant differences in the protein biomarkers in patients with TBI, the model that determined the need for a CT scan validated poorly (AUC=0.64: Cambridge patients). However, using a combination of six metabolites (two amino acids, three sugar derivatives and one ketoacid) it was possible to discriminate patients with intracranial abnormalities on CT and patients with a normal CT (AUC=0.77 in Turku patients and AUC=0.73 in Cambridge patients). Furthermore, a combination of three metabolites could distinguish between diffuse brain injuries and mass lesions (AUC=0.87 in Turku patients and AUC=0.68 in Cambridge patients). This study identifies a set of validated serum polar metabolites, which associate with the need for a CT scan. Additionally, serum metabolites can also predict the nature of the brain injury. These metabolite markers may prevent unnecessary CT scans, thus reducing the cost of diagnostics and radiation load.

Original languageEnglish
JournalJournal of Neurotrauma
Volume35
Issue number22
Pages (from-to)2673–2683
Number of pages10
ISSN0897-7151
DOIs
Publication statusPublished - 1 Nov 2018

ID: 54693945