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Serum insulin-like growth factor 1 in the aging horse

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DOI

  1. Validation of the IDS Octeia ELISA for the determination of insulin-like growth factor 1 in equine serum and tendon tissue extracts

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Molecular indicators of denervation in aging human skeletal muscle

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  3. Muscle-strain injury exudate favors acute tissue healing and prolonged connective tissue formation in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Tone Lygren
  • Sanni Hansen
  • Henning Langberg
  • Julie Fjeldborg
  • Stine Jacobsen
  • Mette O Nielsen
  • Peter Schjerling
  • Bo Markussen
  • Preben D Thomsen
  • Lise C Berg
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BACKGROUND: Insulin-like growth factor 1 (IGF-1) has important roles in anabolic processes in the musculoskeletal system and has been reported to decrease with age in both people and horses.

OBJECTIVES: The objective of this study was to determine serum IGF-1 levels in the aging horse from early to late adulthood (age range 5-27 years).

METHODS: Healthy horses (n = 72) were used in a cross-sectional study, while 37 paired serum samples were available for a longitudinal study. Serum IGF-1 protein was determined using an ELISA kit validated for use in equine samples.

RESULTS: No association was found between serum IGF-1 levels and age in the cross-sectional study. In the longitudinal study, a latent variable model fitted to the data revealed that horses in general experienced a 5.2% increase of serum IGF-1 levels over a 5-year period, but horses crossing a change point around 9 years of age between the 2 samples experienced an 11.0% decrease.

CONCLUSIONS: In this study, there was no evidence for aging being a factor in changes of IGF-1 levels in an adult and old horse population.

Original languageEnglish
JournalVeterinary clinical pathology / American Society for Veterinary Clinical Pathology
Volume43
Issue number4
Pages (from-to)557-60
Number of pages4
ISSN0275-6382
DOIs
Publication statusPublished - Dec 2014

ID: 44834966