Abstract
Serum levels of the gonadal hormones inhibin A and inhibin B are undetectable or low in prepubertal girls, and rise during puberty. In girls with central precocious puberty (CPP) the hypothalamic-pituitary-gonadal axis is prematurely activated, if the girl is thereafter treated with GnRH agonists both gonadotropins and estradiol levels become suppressed. We therefore investigated serum levels of inhibin A and inhibin B in girls with CPP at diagnosis and during treatment in order to test the hypothesis that inhibin secretion would increase and decrease in parallel with the activation and suppression of the hypothalamic-pituitary-gonadal axis. Serum levels of inhibin A and inhibin B were significantly (p <0.0005) elevated in 42 girls at diagnosis of CPP (inhibin A: 7 pg/ml (
| Original language | English |
|---|---|
| Journal | Hormone Research |
| Volume | 54 |
| Issue number | 2 |
| Pages (from-to) | 84-91 |
| Number of pages | 8 |
| ISSN | 0301-0163 |
| DOIs | |
| Publication status | Published - 2000 |
Keywords
- Buserelin
- Child
- Child, Preschool
- Cyproterone Acetate
- Female
- Fertility
- Follow-Up Studies
- Gonadotropin-Releasing Hormone
- Humans
- Inhibins
- Prostatic Secretory Proteins
- Puberty, Precocious
- Triptorelin Pamoate
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