Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Serum gastrin and cholecystokinin are associated with subsequent development of gastric cancer in a prospective cohort of Finnish smokers

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Cohort Profile: DOC*X: a nationwide Danish occupational cohort with eXposure data - an open research resource

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association between genetically predicted polycystic ovary syndrome and ovarian cancer: a Mendelian randomization study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Gastric cancer and gastrin: on the interaction of Helicobacter pylori gastritis and acid inhibitory induced hypergastrinemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Opinion: Stop gaming peer review

    Research output: Contribution to journalComment/debateCommunication

  • Gwen Murphy
  • Christian C Abnet
  • Hyoyoung Choo-Wosoba
  • Emily Vogtmann
  • Stephanie J Weinstein
  • Philip R Taylor
  • Satu Männistö
  • Demetrius Albanes
  • Sanford M Dawsey
  • Jens F Rehfeld
  • Neal D Freedman
View graph of relations

Background: Gastrin, which induces gastric acid secretion, and a structurally similar hormone, cholecystokinin (CCK)-a potent acid inhibitor, may each play a role in gastric cancer. However, few studies have investigated this hypothesis in humans. We therefore investigated whether serum gastrin or CCK concentrations at baseline were associated with the incidence of gastric non-cardia adenocarcinomas (GNCA), oesophagogastric junctional adenocarcinomas (EGJA) or gastric carcinoid tumours over 24 years of follow-up in a study nested within the all-male Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study of Finnish smokers.

Methods: Totals of 283 incident GNCA, 96 EGJA and 10 gastric carcinoid cases, and 778 matched controls, were included in our analysis. Gastrin and CCK were measured using specific radioimmunoassays. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated by multivariable logistic regression with adjustment for all known or suspected confounding factors, including Helicobacter pylori seropositivity.

Results: Those with high gastrin (Q4 vs Q1), had an increased risk of GNCA (fully adjusted OR: 1.92; 95% CI: 1.21, 3.05) and gastric carcinoids, though the small number of carcinoid cases meant the fully adjusted model was unstable (age-adjusted continuous model OR: 4.67; 95% CI: 2.67, 8.15). CCK was associated with risk of GNCA only for those in Q3 relative to Q1 (OR: 0.56; 95% CI: 0.33, 0.96), and no significant trend was observed.

Conclusions: Our data suggest that high serum concentrations of gastrin may be associated independently with an increased risk of gastric cancer; the role of CCK in cancer risk is less clear.

Original languageEnglish
JournalInternational Journal of Epidemiology
Volume46
Issue number3
Pages (from-to)914-923
Number of pages10
ISSN0300-5771
DOIs
Publication statusPublished - 1 Jun 2017

    Research areas

  • Journal Article

ID: 52054323