Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Serotonin 2A receptors contribute to the regulation of risk-averse decisions

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Value and limitations of intracranial recordings for validating electric field modeling for transcranial brain stimulation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The structure of the serotonin system: A PET imaging study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Validation of structural brain connectivity networks: The impact of scanning parameters

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Accessibility of cortical regions to focal TES: Dependence on spatial position, safety, and practical constraints

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Limited colocalization of microbleeds and microstructural changes after severe traumatic brain injury

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Pharmacological studies point to a role of the neurotransmitter serotonin (5-HT) in regulating the preference for risky decisions, yet the functional contribution of specific 5-HT receptors remains to be clarified. We used pharmacological fMRI to investigate the role of the 5-HT2A receptors in processing negative outcomes and regulating risk-averse behavior. During fMRI, twenty healthy volunteers performed a gambling task under two conditions: with or without blocking the 5-HT2A receptors. The volunteers repeatedly chose between small, likely rewards and large, unlikely rewards. Choices were balanced in terms of expected utility and potential loss. Acute blockade of the 5-HT2A receptors with ketanserin made participants more risk-averse. Ketanserin selectively reduced the neural response of the frontopolar cortex to negative outcomes that were caused by low-risk choices and were associated with large missed rewards. In the context of normal 5-HT2A receptor function, ventral striatum displayed a stronger response to low-risk negative outcomes in risk-taking as opposed to risk-averse individuals. This (negative) correlation between the striatal response to low-risk negative outcomes and risk-averse choice behavior was abolished by 5-HT2A receptor blockade. The results provide the first evidence for a critical role of 5-HT2A receptor function in regulating risk-averse behavior. We suggest that the 5-HT2A receptor system facilitates risk-taking behavior by modulating the outcome evaluation of "missed" reward. These results have implications for understanding the neural basis of abnormal risk-taking behavior, for instance in pathological gamblers.
Original languageEnglish
JournalNeuroImage
Volume83C
Pages (from-to)35-44
Number of pages10
ISSN1053-8119
DOIs
Publication statusPublished - 28 Jun 2013

ID: 39916197