Serial studies of cerebral blood flow using 99Tcm-HMPAO: a comparison with 133Xe

A R Andersen, H Friberg, N A Lassen, K Kristensen, R D Neirinckx

37 Citations (Scopus)

Abstract

We have compared the regional distribution of 99Tcm-HMPAO with regional cerebral blood flow (rCBF). CBF was measured by single photon emission computerized tomography (SPECT) using a TOMOMATIC 64 after 133Xe inhalation in 41 patients. With the same SPECT device the distribution of 99Tcm-HMPAO was measured after i.v. injection. High resolution (HR) and low resolution (LR) studies were performed yielding a resolution of 6 to 10 mm (HR) and 15 to 20 (LR). 99Tcm-HMPAO images showed close resemblance to xenon-133 CBF tomograms. Only about 20% of the (decay corrected) brain counts were lost during the first 24 h post injection. A slight decrease in contrast was measured comparing side-to-side asymmetry ratios from the serial studies. This loss of contrast is mainly due to back-diffusion and clearance of a part of the 99Tcm-HMPAO complex from the brain. It could be corrected for by a linearization algorithm. The slight loss of contrast will not be of any importance for the clinical use of this tracer complex.
Original languageEnglish
JournalNuclear Medicine Communications
Volume8
Issue number7
Pages (from-to)549-57
Number of pages9
ISSN0143-3636
Publication statusPublished - Jul 1987

Keywords

  • Brain
  • Brain Diseases
  • Cerebrovascular Circulation
  • Cerebrovascular Disorders
  • Humans
  • Organometallic Compounds
  • Oximes
  • Technetium Tc 99m Exametazime
  • Tomography, Emission-Computed
  • Xenon Radioisotopes

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