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Sensitivity analysis of magnetic field measurements for magnetic resonance electrical impedance tomography (MREIT)

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PURPOSE: Clinical use of magnetic resonance electrical impedance tomography (MREIT) still requires significant sensitivity improvements. Here, the measurement of the current-induced magnetic field (ΔBz,c ) is improved using systematic efficiency analyses and optimization of multi-echo spin echo (MESE) and steady-state free precession free induction decay (SSFP-FID) sequences.

THEORY AND METHODS: Considering T1 , T2 , and T2* relaxation in the signal-to-noise ratios (SNRs) of the MR magnitude images, the efficiency of MESE and SSFP-FID MREIT experiments, and its dependence on the sequence parameters, are analytically analyzed and simulated. The theoretical results are experimentally validated in a saline-filled homogenous spherical phantom with relaxation parameters similar to brain tissue. Measurement of ΔBz,c is also performed in a cylindrical phantom with saline and chicken meat.

RESULTS: The efficiency simulations and experimental results are in good agreement. When using optimal parameters, ΔBz,c can be reliably measured in the phantom even at injected current strengths of 1 mA or lower for both sequence types. The importance of using proper crusher gradient selection on the phase evolution in a MESE experiment is also demonstrated.

CONCLUSION: The efficiencies observed with the optimized sequence parameters will likely render in-vivo human brain MREIT feasible. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.

Original languageEnglish
JournalMagnetic Resonance in Medicine
Volume79
Pages (from-to)748-760
ISSN0740-3194
DOIs
Publication statusPublished - Feb 2018

    Research areas

  • Journal Article

ID: 50574142