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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Senescence rates in patients with end-stage renal disease: a critical appraisal of the Gompertz model

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  • J J E Koopman
  • M P Rozing
  • Ada Kramer
  • D J de Jager
  • D Ansell
  • J M J De Meester
  • K G Prütz
  • P Finne
  • J G Heaf
  • R Palsson
  • R Kramar
  • K J Jager
  • F W Dekker
  • R G J Westendorp
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The most frequently used model to describe the exponential increase in mortality rate over age is the Gompertz equation. Logarithmically transformed, the equation conforms to a straight line, of which the slope has been interpreted as the rate of senescence. Earlier, we proposed the derivative function of the Gompertz equation as a superior descriptor of senescence rate. Here, we tested both measures of the rate of senescence in a population of patients with end-stage renal disease. It is clinical dogma that patients on dialysis experience accelerated senescence, whereas those with a functional kidney transplant have mortality rates comparable to the general population. Therefore, we calculated the age-specific mortality rates for European patients on dialysis (n=274 221; follow-up=594 767 person-years), for European patients with a functioning kidney transplant (n=61 286; follow-up=345 024 person-years), and for the general European population. We found higher mortality rates, but a smaller slope of logarithmic mortality curve for patients on dialysis compared with both patients with a functioning kidney transplant and the general population (P
Original languageEnglish
JournalAging Cell
Volume10
Issue number2
Pages (from-to)233-8
Number of pages6
ISSN1474-9718
DOIs
Publication statusPublished - 2011

    Research areas

  • Adult, Aged, Aged, 80 and over, Aging, Europe, Humans, Kidney Failure, Chronic, Middle Aged, Models, Theoretical, Mortality, Registries, Young Adult

ID: 34725239