Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Semi-Quantitative Calculations of Primary Tumor Metabolic Activity Using F-18 FDG PET/CT as a Predictor of Survival in 92 Patients With High-Grade Bone or Soft Tissue Sarcoma

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Increased risk of incident primary cancer after Staphylococcus aureus bacteremia: A matched cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A national center for persistent severe pain after groin hernia repair: Five-year prospective data

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Classification of death causes after transplantation (CLASS): Evaluation of methodology and initial results

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Collagen Growth Pattern in Human Articular Cartilage of the Knee

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Clinical outcome after surgery on schwannomas in the extremities

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

To assess the prognostic value of primary tumor metabolic activity in patients with high-grade bone sarcomas (BS) or soft tissue sarcomas (STS) using F-18 FDG PET/CT. A single-site, retrospective study including 92 patients with high-grade BS or STS. Pretreatment F-18 FDG PET/CT scan was performed. Clinical data were registered. Accuracy of maximum standardized uptake value of primary tumor (SUVmax) and tumor-to-background (T/B) uptake ratio as prognostic variables and identification of cut-off values to group patients were determined. Kaplan-Meier survival estimates and log-rank test were used to compare survival distributions. Prognostic variables were assessed using Cox proportional hazards regression analysis. Forty-one of 92 patients died during follow-up (45%). Average survival was 6.5 years (95% CI 5.8-7.3 years) and probability of 5-year survival was 52%. Accuracy of SUVmax and T/B uptake ratio as prognostic variables in all patients and during subgroup analysis of patients with STS was significant. No significant results for AUCs were registered in patients with BS. Surgery was independently prognostic for survival throughout multivariate regression analysis of all patients (P = 0.001, HR 3.84) and subgroup analysis (BS: P = 0.02, HR 11.62; STS: P = 0.005, HR 4.13). SUVmax was significant as prognostic variable in all patients (P = 0.02, HR 3.66) and in patients with STS (P = 0.007, HR 3.75). No significant results were demonstrated for T/B uptake ratio. Estimation of primary tumor metabolic activity with pretherapeutic SUVmax using F-18 FDG PET/CT demonstrates independent properties beyond histologic grading for prediction of survival in patients with high-grade STS, but not with high-grade BS.

Original languageEnglish
JournalMedicine (Baltimore)
Volume94
Issue number28
Pages (from-to)e1142
ISSN0025-7974
DOIs
Publication statusPublished - Jul 2015

    Research areas

  • Adolescent, Adult, Aged, Aged, 80 and over, Bone Neoplasms, Child, Denmark, Female, Fluorodeoxyglucose F18, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, ROC Curve, Retrospective Studies, Sarcoma, Soft Tissue Neoplasms, Young Adult

ID: 46228852