Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Self-reported restless legs syndrome and involuntary leg movements during sleep are associated with symptoms of attention deficit hyperactivity disorder

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Assessment of diurnal melatonin, cortisol, activity, and sleep-wake cycle in patients with and without diabetic retinopathy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Mandibular advancement device therapy for obstructive sleep apnea: a prospective study on predictors of treatment success

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Melatonin and cortisol in individuals with spinal cord injury

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Restless legs syndrome is associated with major comorbidities in a population of Danish blood donors

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Plasma Cotinine Cutoff for Distinguishing Smokers From Nonsmokers Among Persons Living With HIV

    Research output: Contribution to journalJournal articleResearch

  2. The Validity of Daily Self-Assessed Perceived Stress Measured Using Smartphones in Healthy Individuals: Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genetic Determinants of Weight Loss After Bariatric Surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Storage time of red blood cells among ICU patients with septic shock

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Restless legs syndrome (RLS) and attention-deficit hyperactivity disorder (ADHD) are disorders with virtually unknown etiologies. Several studies suggest that these disorders are comorbid. However, previous findings may have been influenced by study participants undergoing medical treatments. Thus, the association between RLS and ADHD needs to be investigated in a large population of individuals, not in continuous medical treatment.

MATERIALS AND METHODS: This was a cross-sectional study of 25,336 participants enrolled in the Danish Blood Donor Study from May 1, 2015, to February 1, 2017. Study participants completed the Cambridge-Hopkins RLS questionnaire, reported experience of involuntary leg movements during sleep (ILMS), completed the Adult ADHD Self-Report Scale v.1.1 (ASRS), and provided information on sex, age, body mass index, smoking status, alcohol consumption, whole blood donation history, and self-appraised quality of sleep. Associations between RLS and ADHD symptoms, including subtypes, were examined using multivariate linear- and logistic regression analyses.

RESULTS: Of the 25,336 participants with complete data, 1,322 (5.2%) were classified with RLS, and 653 (2.6%) experienced ADHD symptoms. RLS sufferers were more prone to classify with ADHD according to the full ASRS (OR = 3.57, 95% CI: 3.14-4.0), and they were also more likely to experience ADHD-subtype symptoms (inattention, OR = 1.66, 95% CI: 1.43-1.90; hyperactivity-impulsivity, OR = 1.90, 95% CI: 1.66-2.14). Finally, RLS sufferers with ILMS had increased odds for ADHD symptoms compared with RLS sufferers without (OR = 2.15, 95% CI: 1.30-3.55). This was also observed for the hyperactivity-impulsivity subtype (OR = 5.57, 95% CI: 2.14-14.5).

CONCLUSIONS: RLS and ADHD are associated and may be comorbid disorders.

Original languageEnglish
JournalSleep Medicine
Volume57
Pages (from-to)115-121
Number of pages7
ISSN1389-9457
DOIs
Publication statusPublished - May 2019

ID: 57849132