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Self-reported health status and the associated risk of mortality in heart failure: The DANISH trial

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@article{1c12bf728a044f5aa203840d3b736c94,
title = "Self-reported health status and the associated risk of mortality in heart failure: The DANISH trial",
abstract = "OBJECTIVE: To examine the gradual association between self-reported health status and mortality in patients with heart failure (HF) as current research has focused on poor health status and increased risk of mortality.METHOD: This is a substudy of the DANISH (Defibrillator Implantation in Patients with Nonischemic Systolic HF) trial in which 1116 patients were randomized to receive or not receive an implantable cardioverter-defibrillator. Health status was assessed by a single question of the Short-Form 36. Patients were classified as having excellent/very good, good, fair (reference) or poor health status. We assessed the association between health status and mortality using multivariable Cox proportional hazard models.RESULTS: Self-reported health status was completed by 943 (84{\%}) patients at randomization with a median follow-up of 67 months and a health status distribution of; excellent/very good (n = 79, 8{\%}), good (n = 369, 39{\%}), fair (n = 409, 43{\%}), and poor (n = 86, 9{\%}). All-cause mortality (death events/ 100 person-years) occurred with gradual differences according to health status from excellent/ very good (2.14), good (3.74), fair (5.21) to poor health status (5.57). The gradual difference yielded a crude hazard ratio (HR) of 0.40, 95{\%} CI 0.20-0.80 (adjusted HR 0.47 (95{\%} CI 0.23-0.95) for excellent/ very good health status, HR 0.71, 95{\%} CI 0.52-0.97 (adjusted HR 0.78 (95{\%} CI 0.56-1.08) for good health status. Poor being worse than fair health status yielded a crude HR of 1.07, 95{\%} CI 0.67-1.69.CONCLUSION: Excellent/very good self-reported health status as assessed by a single question was associated with lower long-term mortality in patients with HF.",
author = "Bundgaard, {Johan S} and Thune, {Jens J} and Christian Torp-Pedersen and Nielsen, {Jens C} and Jens Haarbo and Rasmus R{\o}rth and Lars Videb{\ae}k and Thomas Melchior and Pedersen, {Susanne S} and Lars K{\o}ber and Mogensen, {Ulrik M}",
note = "Copyright {\circledC} 2020 Elsevier Inc. All rights reserved.",
year = "2020",
month = "10",
doi = "10.1016/j.jpsychores.2020.110220",
language = "English",
volume = "137",
pages = "110220",
journal = "Journal of Psychosomatic Research",
issn = "0022-3999",
publisher = "Elsevier Inc",

}

RIS

TY - JOUR

T1 - Self-reported health status and the associated risk of mortality in heart failure

T2 - The DANISH trial

AU - Bundgaard, Johan S

AU - Thune, Jens J

AU - Torp-Pedersen, Christian

AU - Nielsen, Jens C

AU - Haarbo, Jens

AU - Rørth, Rasmus

AU - Videbæk, Lars

AU - Melchior, Thomas

AU - Pedersen, Susanne S

AU - Køber, Lars

AU - Mogensen, Ulrik M

N1 - Copyright © 2020 Elsevier Inc. All rights reserved.

PY - 2020/10

Y1 - 2020/10

N2 - OBJECTIVE: To examine the gradual association between self-reported health status and mortality in patients with heart failure (HF) as current research has focused on poor health status and increased risk of mortality.METHOD: This is a substudy of the DANISH (Defibrillator Implantation in Patients with Nonischemic Systolic HF) trial in which 1116 patients were randomized to receive or not receive an implantable cardioverter-defibrillator. Health status was assessed by a single question of the Short-Form 36. Patients were classified as having excellent/very good, good, fair (reference) or poor health status. We assessed the association between health status and mortality using multivariable Cox proportional hazard models.RESULTS: Self-reported health status was completed by 943 (84%) patients at randomization with a median follow-up of 67 months and a health status distribution of; excellent/very good (n = 79, 8%), good (n = 369, 39%), fair (n = 409, 43%), and poor (n = 86, 9%). All-cause mortality (death events/ 100 person-years) occurred with gradual differences according to health status from excellent/ very good (2.14), good (3.74), fair (5.21) to poor health status (5.57). The gradual difference yielded a crude hazard ratio (HR) of 0.40, 95% CI 0.20-0.80 (adjusted HR 0.47 (95% CI 0.23-0.95) for excellent/ very good health status, HR 0.71, 95% CI 0.52-0.97 (adjusted HR 0.78 (95% CI 0.56-1.08) for good health status. Poor being worse than fair health status yielded a crude HR of 1.07, 95% CI 0.67-1.69.CONCLUSION: Excellent/very good self-reported health status as assessed by a single question was associated with lower long-term mortality in patients with HF.

AB - OBJECTIVE: To examine the gradual association between self-reported health status and mortality in patients with heart failure (HF) as current research has focused on poor health status and increased risk of mortality.METHOD: This is a substudy of the DANISH (Defibrillator Implantation in Patients with Nonischemic Systolic HF) trial in which 1116 patients were randomized to receive or not receive an implantable cardioverter-defibrillator. Health status was assessed by a single question of the Short-Form 36. Patients were classified as having excellent/very good, good, fair (reference) or poor health status. We assessed the association between health status and mortality using multivariable Cox proportional hazard models.RESULTS: Self-reported health status was completed by 943 (84%) patients at randomization with a median follow-up of 67 months and a health status distribution of; excellent/very good (n = 79, 8%), good (n = 369, 39%), fair (n = 409, 43%), and poor (n = 86, 9%). All-cause mortality (death events/ 100 person-years) occurred with gradual differences according to health status from excellent/ very good (2.14), good (3.74), fair (5.21) to poor health status (5.57). The gradual difference yielded a crude hazard ratio (HR) of 0.40, 95% CI 0.20-0.80 (adjusted HR 0.47 (95% CI 0.23-0.95) for excellent/ very good health status, HR 0.71, 95% CI 0.52-0.97 (adjusted HR 0.78 (95% CI 0.56-1.08) for good health status. Poor being worse than fair health status yielded a crude HR of 1.07, 95% CI 0.67-1.69.CONCLUSION: Excellent/very good self-reported health status as assessed by a single question was associated with lower long-term mortality in patients with HF.

U2 - 10.1016/j.jpsychores.2020.110220

DO - 10.1016/j.jpsychores.2020.110220

M3 - Journal article

VL - 137

SP - 110220

JO - Journal of Psychosomatic Research

JF - Journal of Psychosomatic Research

SN - 0022-3999

ER -

ID: 60806494