Secretion of parathyroid hormone may be coupled to insulin secretion in humans

Marie Reeberg Sass; Nicolai Jacob Wewer Albrechtsen; Jens Pedersen; Kristine Juul Hare; Nis Borbye-Lorenzen; Katalin Kiss; Tina Vilsbøll; Filip Krag Knop; Steen Seier Poulsen; Niklas Rye Jørgensen; Jens Juul Holst; Cathrine Ørskov; Bolette Hartmann

doi:10.1530/EC-20-0092

Secretion of parathyroid hormone may be coupled to insulin secretion in humans

Marie Reeberg Sass, Nicolai Jacob Wewer Albrechtsen, Jens Pedersen, Kristine Juul Hare, Nis Borbye-Lorenzen, Katalin Kiss, Tina Vilsbøll, Filip Krag Knop, Steen Seier Poulsen, Niklas Rye Jørgensen, Jens Juul Holst, Cathrine Ørskov, Bolette Hartmann

12 Citations (Scopus)

Abstract

Objective: Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown. We hypothesized that insulin acts as an acute regulator of PTH secretion.

Methods: Intact PTH was measured in plasma from patients with T1D and matched healthy individuals during 4-h oral glucose tolerance tests (OGTT) and isoglycemic i.v. glucose infusions on 2 separate days. In addition, expression of insulin receptors on surgical specimens of parathyroid glands was assessed by immunochemistry (IHC) and quantitative PCR (qPCR).

Results: The inhibition of PTH secretion was more pronounced in healthy individuals compared to patients with T1D during an OGTT (decrementalAUC0-240min: -5256 ± 3954 min × ng/L and -2408 ± 1435 min × ng/L, P = 0.030). Insulin levels correlated significantly and inversely with PTH levels, also after adjusting for levels of several gut hormones and BMI (P = 0.002). Expression of insulin receptors in human parathyroid glands was detected by both IHC and qPCR.

Conclusion: Our study suggests that insulin may act as an acute regulator of PTH secretion in humans.

Original language	English
Journal	Endocrine Connections
Volume	9
Issue number	7
Pages (from-to)	747-754
Number of pages	8
ISSN	2049-3614
DOIs	https://doi.org/10.1530/EC-20-0092
Publication status	Published - Jul 2020

Keywords

IGF1 receptor
IGF2 receptor
IIGI
Insulin receptor
OGTT
T1DM

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10.1530/EC-20-0092

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title = "Secretion of parathyroid hormone may be coupled to insulin secretion in humans",

abstract = "Objective: Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown. We hypothesized that insulin acts as an acute regulator of PTH secretion.Methods: Intact PTH was measured in plasma from patients with T1D and matched healthy individuals during 4-h oral glucose tolerance tests (OGTT) and isoglycemic i.v. glucose infusions on 2 separate days. In addition, expression of insulin receptors on surgical specimens of parathyroid glands was assessed by immunochemistry (IHC) and quantitative PCR (qPCR).Results: The inhibition of PTH secretion was more pronounced in healthy individuals compared to patients with T1D during an OGTT (decrementalAUC0-240min: -5256 ± 3954 min × ng/L and -2408 ± 1435 min × ng/L, P = 0.030). Insulin levels correlated significantly and inversely with PTH levels, also after adjusting for levels of several gut hormones and BMI (P = 0.002). Expression of insulin receptors in human parathyroid glands was detected by both IHC and qPCR.Conclusion: Our study suggests that insulin may act as an acute regulator of PTH secretion in humans.",

keywords = "IGF1 receptor, IGF2 receptor, IIGI, Insulin receptor, OGTT, T1DM",

author = "Sass, \{Marie Reeberg\} and \{Wewer Albrechtsen\}, \{Nicolai Jacob\} and Jens Pedersen and Hare, \{Kristine Juul\} and Nis Borbye-Lorenzen and Katalin Kiss and Tina Vilsb{\o}ll and Knop, \{Filip Krag\} and Poulsen, \{Steen Seier\} and J{\o}rgensen, \{Niklas Rye\} and Holst, \{Jens Juul\} and Cathrine {\O}rskov and Bolette Hartmann",

year = "2020",

month = jul,

doi = "10.1530/EC-20-0092",

language = "English",

volume = "9",

pages = "747--754",

journal = "Endocrine Connections",

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number = "7",

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T1 - Secretion of parathyroid hormone may be coupled to insulin secretion in humans

AU - Sass, Marie Reeberg

AU - Wewer Albrechtsen, Nicolai Jacob

AU - Pedersen, Jens

AU - Hare, Kristine Juul

AU - Borbye-Lorenzen, Nis

AU - Kiss, Katalin

AU - Vilsbøll, Tina

AU - Knop, Filip Krag

AU - Poulsen, Steen Seier

AU - Jørgensen, Niklas Rye

AU - Holst, Jens Juul

AU - Ørskov, Cathrine

AU - Hartmann, Bolette

PY - 2020/7

Y1 - 2020/7

N2 - Objective: Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown. We hypothesized that insulin acts as an acute regulator of PTH secretion.Methods: Intact PTH was measured in plasma from patients with T1D and matched healthy individuals during 4-h oral glucose tolerance tests (OGTT) and isoglycemic i.v. glucose infusions on 2 separate days. In addition, expression of insulin receptors on surgical specimens of parathyroid glands was assessed by immunochemistry (IHC) and quantitative PCR (qPCR).Results: The inhibition of PTH secretion was more pronounced in healthy individuals compared to patients with T1D during an OGTT (decrementalAUC0-240min: -5256 ± 3954 min × ng/L and -2408 ± 1435 min × ng/L, P = 0.030). Insulin levels correlated significantly and inversely with PTH levels, also after adjusting for levels of several gut hormones and BMI (P = 0.002). Expression of insulin receptors in human parathyroid glands was detected by both IHC and qPCR.Conclusion: Our study suggests that insulin may act as an acute regulator of PTH secretion in humans.

AB - Objective: Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown. We hypothesized that insulin acts as an acute regulator of PTH secretion.Methods: Intact PTH was measured in plasma from patients with T1D and matched healthy individuals during 4-h oral glucose tolerance tests (OGTT) and isoglycemic i.v. glucose infusions on 2 separate days. In addition, expression of insulin receptors on surgical specimens of parathyroid glands was assessed by immunochemistry (IHC) and quantitative PCR (qPCR).Results: The inhibition of PTH secretion was more pronounced in healthy individuals compared to patients with T1D during an OGTT (decrementalAUC0-240min: -5256 ± 3954 min × ng/L and -2408 ± 1435 min × ng/L, P = 0.030). Insulin levels correlated significantly and inversely with PTH levels, also after adjusting for levels of several gut hormones and BMI (P = 0.002). Expression of insulin receptors in human parathyroid glands was detected by both IHC and qPCR.Conclusion: Our study suggests that insulin may act as an acute regulator of PTH secretion in humans.

KW - IGF1 receptor

KW - IGF2 receptor

KW - IIGI

KW - Insulin receptor

KW - OGTT

KW - T1DM

UR - https://www.scopus.com/pages/publications/85088976515

U2 - 10.1530/EC-20-0092

DO - 10.1530/EC-20-0092

M3 - Journal article

C2 - 32698134

SN - 2049-3614

VL - 9

SP - 747

EP - 754

JO - Endocrine Connections

JF - Endocrine Connections

IS - 7

ER -

Secretion of parathyroid hormone may be coupled to insulin secretion in humans

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