Seasonality of cardiovascular risk factors: an analysis including over 230 000 participants in 15 countries

Helena Marti-Soler; Cédric Gubelmann; Stefanie Aeschbacher; Luis Alves; Martin Bobak; Vanina Bongard; Els Clays; Giovanni de Gaetano; Augusto Di Castelnuovo; Roberto Elosua; Jean Ferrieres; Idris Guessous; Jannicke Igland; Torben Jørgensen; Yuri Nikitin; Mark G O'Doherty; Luigi Palmieri; Rafel Ramos; Judith Simons; Gerhard Sulo; Diego Vanuzzo; Joan Vila; Henrique Barros; Anders Borglykke; David Conen; Dirk De Bacquer; Chiara Donfrancesco; Jean-Michel Gaspoz; Simona Giampaoli; Graham G Giles; Licia Iacoviello; Frank Kee; Ruzena Kubinova; Sofia Malyutina; Jaume Marrugat; Eva Prescott; Jean Bernard Ruidavets; Robert Scragg; Leon A Simons; Abdonas Tamosiunas; Grethe S Tell; Peter Vollenweider; Pedro Marques-Vidal

doi:10.1136/heartjnl-2014-305623

Seasonality of cardiovascular risk factors: an analysis including over 230 000 participants in 15 countries

Helena Marti-Soler, Cédric Gubelmann, Stefanie Aeschbacher, Luis Alves, Martin Bobak, Vanina Bongard, Els Clays, Giovanni de Gaetano, Augusto Di Castelnuovo, Roberto Elosua, Jean Ferrieres, Idris Guessous, Jannicke Igland, Torben Jørgensen, Yuri Nikitin, Mark G O'Doherty, Luigi Palmieri, Rafel Ramos, Judith Simons, Gerhard SuloDiego Vanuzzo, Joan Vila, Henrique Barros, Anders Borglykke, David Conen, Dirk De Bacquer, Chiara Donfrancesco, Jean-Michel Gaspoz, Simona Giampaoli, Graham G Giles, Licia Iacoviello, Frank Kee, Ruzena Kubinova, Sofia Malyutina, Jaume Marrugat, Eva Prescott, Jean Bernard Ruidavets, Robert Scragg, Leon A Simons, Abdonas Tamosiunas, Grethe S Tell, Peter Vollenweider, Pedro Marques-Vidal

Cardiology, Department of

100 Citations (Scopus)

Abstract

OBJECTIVE: To assess the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies.

METHODS: Cross-sectional data from 24 population-based studies from 15 countries, with a total sample size of 237 979 subjects. CVRFs included Body Mass Index (BMI) and waist circumference; systolic (SBP) and diastolic (DBP) blood pressure; total, high (HDL) and low (LDL) density lipoprotein cholesterol; triglycerides and glucose levels. Within each study, all data were adjusted for age, gender and current smoking. For blood pressure, lipids and glucose levels, further adjustments on BMI and drug treatment were performed.

RESULTS: In the Northern and Southern Hemispheres, CVRFs levels tended to be higher in winter and lower in summer months. These patterns were observed for most studies. In the Northern Hemisphere, the estimated seasonal variations were 0.26 kg/m(2) for BMI, 0.6 cm for waist circumference, 2.9 mm Hg for SBP, 1.4 mm Hg for DBP, 0.02 mmol/L for triglycerides, 0.10 mmol/L for total cholesterol, 0.01 mmol/L for HDL cholesterol, 0.11 mmol/L for LDL cholesterol, and 0.07 mmol/L for glycaemia. Similar results were obtained when the analysis was restricted to studies collecting fasting blood samples. Similar seasonal variations were found for most CVRFs in the Southern Hemisphere, with the exception of waist circumference, HDL, and LDL cholesterol.

CONCLUSIONS: CVRFs show a seasonal pattern characterised by higher levels in winter, and lower levels in summer. This pattern could contribute to the seasonality of CV mortality.

Original language	English
Journal	Heart (British Cardiac Society)
Volume	100
Pages (from-to)	1517-1523
ISSN	1355-6037
DOIs	https://doi.org/10.1136/heartjnl-2014-305623
Publication status	Published - 30 May 2014

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Marti-Soler, H., Gubelmann, C., Aeschbacher, S., Alves, L., Bobak, M., Bongard, V., Clays, E., de Gaetano, G., Di Castelnuovo, A., Elosua, R., Ferrieres, J., Guessous, I., Igland, J., Jørgensen, T., Nikitin, Y., O'Doherty, M. G., Palmieri, L., Ramos, R., Simons, J., ... Marques-Vidal, P. (2014). Seasonality of cardiovascular risk factors: an analysis including over 230 000 participants in 15 countries. Heart (British Cardiac Society), 100, 1517-1523. https://doi.org/10.1136/heartjnl-2014-305623

Marti-Soler, H, Gubelmann, C, Aeschbacher, S, Alves, L, Bobak, M, Bongard, V, Clays, E, de Gaetano, G, Di Castelnuovo, A, Elosua, R, Ferrieres, J, Guessous, I, Igland, J, Jørgensen, T, Nikitin, Y, O'Doherty, MG, Palmieri, L, Ramos, R, Simons, J, Sulo, G, Vanuzzo, D, Vila, J, Barros, H, Borglykke, A, Conen, D, De Bacquer, D, Donfrancesco, C, Gaspoz, J-M, Giampaoli, S, Giles, GG, Iacoviello, L, Kee, F, Kubinova, R, Malyutina, S, Marrugat, J, Prescott, E, Ruidavets, JB, Scragg, R, Simons, LA, Tamosiunas, A, Tell, GS, Vollenweider, P & Marques-Vidal, P 2014, 'Seasonality of cardiovascular risk factors: an analysis including over 230 000 participants in 15 countries', Heart (British Cardiac Society), vol. 100, pp. 1517-1523. https://doi.org/10.1136/heartjnl-2014-305623

@article{00d08ae302a342d2b5bd1cca962cf751,

title = "Seasonality of cardiovascular risk factors: an analysis including over 230 000 participants in 15 countries",

abstract = "OBJECTIVE: To assess the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies.METHODS: Cross-sectional data from 24 population-based studies from 15 countries, with a total sample size of 237 979 subjects. CVRFs included Body Mass Index (BMI) and waist circumference; systolic (SBP) and diastolic (DBP) blood pressure; total, high (HDL) and low (LDL) density lipoprotein cholesterol; triglycerides and glucose levels. Within each study, all data were adjusted for age, gender and current smoking. For blood pressure, lipids and glucose levels, further adjustments on BMI and drug treatment were performed.RESULTS: In the Northern and Southern Hemispheres, CVRFs levels tended to be higher in winter and lower in summer months. These patterns were observed for most studies. In the Northern Hemisphere, the estimated seasonal variations were 0.26 kg/m(2) for BMI, 0.6 cm for waist circumference, 2.9 mm Hg for SBP, 1.4 mm Hg for DBP, 0.02 mmol/L for triglycerides, 0.10 mmol/L for total cholesterol, 0.01 mmol/L for HDL cholesterol, 0.11 mmol/L for LDL cholesterol, and 0.07 mmol/L for glycaemia. Similar results were obtained when the analysis was restricted to studies collecting fasting blood samples. Similar seasonal variations were found for most CVRFs in the Southern Hemisphere, with the exception of waist circumference, HDL, and LDL cholesterol.CONCLUSIONS: CVRFs show a seasonal pattern characterised by higher levels in winter, and lower levels in summer. This pattern could contribute to the seasonality of CV mortality.",

author = "Helena Marti-Soler and C{\'e}dric Gubelmann and Stefanie Aeschbacher and Luis Alves and Martin Bobak and Vanina Bongard and Els Clays and {de Gaetano}, Giovanni and {Di Castelnuovo}, Augusto and Roberto Elosua and Jean Ferrieres and Idris Guessous and Jannicke Igland and Torben J{\o}rgensen and Yuri Nikitin and O'Doherty, {Mark G} and Luigi Palmieri and Rafel Ramos and Judith Simons and Gerhard Sulo and Diego Vanuzzo and Joan Vila and Henrique Barros and Anders Borglykke and David Conen and {De Bacquer}, Dirk and Chiara Donfrancesco and Jean-Michel Gaspoz and Simona Giampaoli and Giles, {Graham G} and Licia Iacoviello and Frank Kee and Ruzena Kubinova and Sofia Malyutina and Jaume Marrugat and Eva Prescott and Ruidavets, {Jean Bernard} and Robert Scragg and Simons, {Leon A} and Abdonas Tamosiunas and Tell, {Grethe S} and Peter Vollenweider and Pedro Marques-Vidal",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",

year = "2014",

month = may,

day = "30",

doi = "10.1136/heartjnl-2014-305623",

language = "English",

volume = "100",

pages = "1517--1523",

journal = "Heart",

issn = "1355-6037",

publisher = "B M J Group",

}

TY - JOUR

T1 - Seasonality of cardiovascular risk factors

T2 - an analysis including over 230 000 participants in 15 countries

AU - Marti-Soler, Helena

AU - Gubelmann, Cédric

AU - Aeschbacher, Stefanie

AU - Alves, Luis

AU - Bobak, Martin

AU - Bongard, Vanina

AU - Clays, Els

AU - de Gaetano, Giovanni

AU - Di Castelnuovo, Augusto

AU - Elosua, Roberto

AU - Ferrieres, Jean

AU - Guessous, Idris

AU - Igland, Jannicke

AU - Jørgensen, Torben

AU - Nikitin, Yuri

AU - O'Doherty, Mark G

AU - Palmieri, Luigi

AU - Ramos, Rafel

AU - Simons, Judith

AU - Sulo, Gerhard

AU - Vanuzzo, Diego

AU - Vila, Joan

AU - Barros, Henrique

AU - Borglykke, Anders

AU - Conen, David

AU - De Bacquer, Dirk

AU - Donfrancesco, Chiara

AU - Gaspoz, Jean-Michel

AU - Giampaoli, Simona

AU - Giles, Graham G

AU - Iacoviello, Licia

AU - Kee, Frank

AU - Kubinova, Ruzena

AU - Malyutina, Sofia

AU - Marrugat, Jaume

AU - Prescott, Eva

AU - Ruidavets, Jean Bernard

AU - Scragg, Robert

AU - Simons, Leon A

AU - Tamosiunas, Abdonas

AU - Tell, Grethe S

AU - Vollenweider, Peter

AU - Marques-Vidal, Pedro

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2014/5/30

Y1 - 2014/5/30

N2 - OBJECTIVE: To assess the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies.METHODS: Cross-sectional data from 24 population-based studies from 15 countries, with a total sample size of 237 979 subjects. CVRFs included Body Mass Index (BMI) and waist circumference; systolic (SBP) and diastolic (DBP) blood pressure; total, high (HDL) and low (LDL) density lipoprotein cholesterol; triglycerides and glucose levels. Within each study, all data were adjusted for age, gender and current smoking. For blood pressure, lipids and glucose levels, further adjustments on BMI and drug treatment were performed.RESULTS: In the Northern and Southern Hemispheres, CVRFs levels tended to be higher in winter and lower in summer months. These patterns were observed for most studies. In the Northern Hemisphere, the estimated seasonal variations were 0.26 kg/m(2) for BMI, 0.6 cm for waist circumference, 2.9 mm Hg for SBP, 1.4 mm Hg for DBP, 0.02 mmol/L for triglycerides, 0.10 mmol/L for total cholesterol, 0.01 mmol/L for HDL cholesterol, 0.11 mmol/L for LDL cholesterol, and 0.07 mmol/L for glycaemia. Similar results were obtained when the analysis was restricted to studies collecting fasting blood samples. Similar seasonal variations were found for most CVRFs in the Southern Hemisphere, with the exception of waist circumference, HDL, and LDL cholesterol.CONCLUSIONS: CVRFs show a seasonal pattern characterised by higher levels in winter, and lower levels in summer. This pattern could contribute to the seasonality of CV mortality.

AB - OBJECTIVE: To assess the seasonality of cardiovascular risk factors (CVRF) in a large set of population-based studies.METHODS: Cross-sectional data from 24 population-based studies from 15 countries, with a total sample size of 237 979 subjects. CVRFs included Body Mass Index (BMI) and waist circumference; systolic (SBP) and diastolic (DBP) blood pressure; total, high (HDL) and low (LDL) density lipoprotein cholesterol; triglycerides and glucose levels. Within each study, all data were adjusted for age, gender and current smoking. For blood pressure, lipids and glucose levels, further adjustments on BMI and drug treatment were performed.RESULTS: In the Northern and Southern Hemispheres, CVRFs levels tended to be higher in winter and lower in summer months. These patterns were observed for most studies. In the Northern Hemisphere, the estimated seasonal variations were 0.26 kg/m(2) for BMI, 0.6 cm for waist circumference, 2.9 mm Hg for SBP, 1.4 mm Hg for DBP, 0.02 mmol/L for triglycerides, 0.10 mmol/L for total cholesterol, 0.01 mmol/L for HDL cholesterol, 0.11 mmol/L for LDL cholesterol, and 0.07 mmol/L for glycaemia. Similar results were obtained when the analysis was restricted to studies collecting fasting blood samples. Similar seasonal variations were found for most CVRFs in the Southern Hemisphere, with the exception of waist circumference, HDL, and LDL cholesterol.CONCLUSIONS: CVRFs show a seasonal pattern characterised by higher levels in winter, and lower levels in summer. This pattern could contribute to the seasonality of CV mortality.

U2 - 10.1136/heartjnl-2014-305623

DO - 10.1136/heartjnl-2014-305623

M3 - Journal article

C2 - 24879630

VL - 100

SP - 1517

EP - 1523

JO - Heart

JF - Heart

SN - 1355-6037

ER -

Seasonality of cardiovascular risk factors: an analysis including over 230 000 participants in 15 countries

Abstract

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