Abstract
Abstract The objective was to examine the applicability of the two biochemical markers PAPP-A and free beta-hCG for fetal trisomy 21 (T21) in very early pregnancy: gestational weeks (GA) 6 and 7. Medians for the two markers were generated on 36,745 fetal T21 unaffected pregnancies from gestational weeks 6-14. Concentrations were converted to Multiples of the Medians (MoMs). Median MoM from T21 affected pregnancies were compared over three intervals of gestational age; the very early weeks 6 and 7, weeks 8-10 and weeks 11-14. Median MoM from 9 affected pregnancies with a very early blood sample had a PAPP-A median MoM of 0.269, compared to 0.392 in weeks 8-10 and 0.531 in weeks 11-14. On the contrary, free beta-hCG diverged from the median with increasing gestational age. Our data suggest that PAPP-A is a useful marker for very early testing in first trimester screening for fetal T21.
| Original language | English |
|---|---|
| Journal | Acta Obstetricia et Gynecologica Scandinavica |
| Volume | 89 |
| Issue number | 9 |
| Pages (from-to) | 1218-21 |
| Number of pages | 4 |
| ISSN | 0001-6349 |
| DOIs | |
| Publication status | Published - 2010 |
| Externally published | Yes |
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